PMID: 9166129Apr 1, 1997Paper

delta-Aminolevulinic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid

Occupational and Environmental Medicine
B S SchwartzK T Kelsey

Abstract

Previous research suggests that binding of lead by delta-aminolevulinic acid dehydratase (ALAD) may vary by ALAD genotype. This hypothesis was tested by examining whether ALAD genotype modifies urinary lead excretion (DMSA chelatable lead) after oral administration of dimercaptosuccinic acid (DMSA). 57 South Korean lead battery manufacturing workers were given 5 mg/kg oral DMSA and urine was collected for four hours. Male workers were randomly selected from two ALAD genotype strata (ALAD1-1, ALAD1-2) from among all current workers in the two plants (n = 290). Subjects with ALAD1-1 (n = 38) were frequency matched with subjects with ALAD1-2 (n = 19) on duration of employment in the lead industry. Blood lead, zinc protoporphyrin, and plasma aminolevulinic acid concentrations, as well as ALAD genotype, duration of exposure, current tobacco use, and weight were examined as predictors or effect modifiers of levels of DMSA chelatable lead. Blood lead concentrations ranged from 11 to 53 micrograms/dl, with a mean (SD) of 25.4 (10.2) micrograms/dl. After 5 mg/kg DMSA orally, the workers excreted a mean (SD) 85.4 (45.0) micrograms lead during a four hour urine collection (range 16.5-184.1 micrograms). After controlling for blood lead con...Continue Reading

References

Sep 1, 1979·International Archives of Occupational and Environmental Health·L AlessioC Zocchetti
Apr 1, 1992·Scandinavian Journal of Work, Environment & Health·I TellS Skerfving
May 1, 1989·Clinical Pharmacology and Therapeutics·H V AposhianD F Perry
Apr 1, 1985·Clinical Pharmacology and Therapeutics·J H GrazianoL Turgeon
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WetmurR J Desnick
Jan 1, 1986·International Archives of Occupational and Environmental Health·B ZiemsenH W Goedde
Jul 1, 1973·Health Physics·F W BruengerB J Stover
Aug 1, 1980·British Journal of Industrial Medicine·C N Ong, W R Lee
Jan 1, 1981·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·J P HansenP E Paulev
Jul 1, 1981·Annals of Human Genetics·G BattistuzziS Caiola
Jan 1, 1995·Occupational and Environmental Medicine·B K LeeK D Ahn
Mar 1, 1994·Archives of Environmental Health·D BellingerH L Needleman

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Citations

Aug 15, 2000·American Journal of Industrial Medicine·T SakaiT Yoshida
Feb 3, 2012·Biochemical Genetics·Ana O MoreiraJoão Paulo Teixeira
Oct 30, 2007·Journal of Toxicology and Environmental Health. Part a·Yang ZhaoFeng Chen
Jul 29, 2011·Journal of Occupational and Environmental Hygiene·Perry Gottesfeld, Amod K Pokhrel
Dec 7, 2000·The Journal of the Acoustical Society of America·C MagalJ Casas
May 26, 1999·Occupational and Environmental Medicine·B S SchwartzJ M Links
Feb 13, 2001·Occupational and Environmental Medicine·A C ToddB S Schwartz
Mar 4, 2000·Environmental Health Perspectives·A O Onalaja, L Claudio
Jun 27, 2003·Environmental Health Perspectives·Samir N KeladaMuin J Khoury
Apr 14, 2007·Environmental Health Perspectives·Brian S Schwartz, Howard Hu
May 15, 2009·International Journal of Environmental Research and Public Health·Koichi MiyakiTakeo Nakayama
Mar 1, 2004·Human Nature : an Interdisciplinary Biosocial Perspective·Sara E Johnson, John Bock
Aug 22, 2007·American Journal of Clinical Pathology·Amitava Dasgupta
Mar 21, 2007·Environmental Health Perspectives·Franco ScinicarielloBruce A Fowler
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Preetha RajaramanPeter D Inskip
Feb 5, 1999·Environmental Research·P SithisarankulP T Strickland

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