PMID: 9551848Apr 29, 1998Paper

Delta-aminolevulinic acid-induced lipid peroxidation in rat kidney and liver is attenuated by melatonin: an in vitro and in vivo study

Journal of Pineal Research
R C Carneiro, R J Reiter

Abstract

Acute intermittent porphyria (AIP) is a genetically inherited disease characterized by a partial block in liver heme biosynthesis and by increased urinary excretion of the delta-aminolevulinic acid (ALA). Recently, it has been proposed that the toxic effects of ALA are related to the generation of free radicals. In the present study the in vitro and in vivo effect of melatonin, a recently described antioxidative agent, on ALA-induced lipid peroxidation in rat liver and kidney was determined. The concentration of malonaldehyde (MDA) and 4-hydroxyalkenals (4-HDA) was assayed as an index of induced membrane oxidative damage. In vitro melatonin protected, in a concentration-dependent manner, against ALA-induced lipid peroxidation in liver and kidney homogenates. In in vivo experiments as well, it was demonstrated that ALA (40 mg/kg)-induced lipid peroxidation in liver and kidney was reduced by acute melatonin (10 mg/kg) treatment. The results support the involvement of free radicals in ALA toxicity and show that in vitro and in vivo melatonin confers protection against this toxicity, likely due to the antioxidative capability of the indole.

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Citations

Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·M KarbownikR J Reiter
Feb 14, 2002·Free Radical Biology & Medicine·Gamal H El-SokkaryRussel J Reiter
Nov 25, 2000·The International Journal of Biochemistry & Cell Biology·M KarbownikD Tan
Jun 13, 2000·Cancer Biotherapy & Radiopharmaceuticals·A M BerghellaD Adorno
Feb 24, 2001·Fundamental & Clinical Pharmacology·G SenerM Keyer-Uysa
Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Jan 1, 2014·Antioxidants·Daniel P CardinaliLuis I Brusco
Aug 19, 2009·Neurotoxicology and Teratology·Edward F KriegUNKNOWN CDC/NCI NHANES III Genomics Working Group
Nov 9, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Natalia M FelitsynPeter W Stacpoole
Oct 13, 2017·Journal of Cellular Physiology·Keywan Mortezaee, Neda Khanlarkhani

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