Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system

Experimental Brain Research
M SchwarzK H Sontag

Abstract

The action of delta-aminovaleric acid (AVA) on the muscle relaxant properties of baclofen, a GABAB receptor agonist, was investigated in two experimental models: (1) the pathologically increased muscle tone of the gastrocnemius muscle in spastic mutant Han-Wistar rats and (2) the Hoffmann (H)-reflex recorded from plantar foot muscles after electrical stimulation of the tibial nerve in barbiturate (60 mg/kg) anaesthetized rats. In both paradigms coadministration of AVA (500 nmol/5 microliter) antagonized the muscle relaxant action of intrathecally applied baclofen (0.2-2 nmol), but failed to affect the muscle relaxant effects of intrathecally injected muscimol (2-20 nmol). In contrast, coadministration of bicuculline (1 nmol) did block the muscle relaxant action of muscimol, but failed to alter the effects of baclofen. When administered alone, bicuculline (1 nmol), or AVA (500 nmol-2 mumol) were without intrinsic action in both paradigms. In an additional series of experiments we investigated the action of AVA on a supraspinal effect of baclofen. Coadministration of AVA (12.5 nmol/0.5 microliter) in the ventromedial thalamic nucleus antagonized the catalepsy induced by baclofen (ED50 10 pmol/0.5 microliter), as indicated by an i...Continue Reading

Citations

Mar 24, 1999·Neuroscience and Behavioral Physiology·I V BatuevaN P Veselkin
Aug 31, 1992·Neuroscience Letters·M SchwarzK H Sontag
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Anshu ManochaPramod Kumari Mediratta
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Anshu ManochaKrishna Kishore Sharma
Aug 11, 2001·Journal of Neuroimmunology·J S KuoC M Hsueh
Oct 1, 1995·Neurochemical Research·R K SimpsonJ C Goodman
Sep 6, 2005·Pharmacology, Biochemistry, and Behavior·Anshu ManochaPramod Kumari Mediratta

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