Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.

Molecules and Cells
Ilhwan YangKwonseop Kim

Abstract

E-cadherin is a member of the cadherin family of Ca(2+)-dependent cell-cell adhesion molecules. p120-Catenin and delta-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and delta-catenin for E-cadherin has not been fully explained. In this report, we show that cells overexpressing delta-catenin contain less p120-catenin than control cells at the cell-cell interface and that this causes the relocalization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by either one to E-cadherin adversely affects the stability of the other.

References

Oct 1, 1995·Current Opinion in Cell Biology·M Takeichi
Apr 17, 1999·Molecular and Cellular Biology·J M Daniel, A B Reynolds
Nov 5, 1999·Molecular Cell Biology Research Communications : MCBRC·F NolletF van Roy
Jan 12, 2000·The Journal of Cell Biology·M A ThoresonA B Reynolds
Mar 23, 2000·Cancer Metastasis Reviews·L Waltzer, M Bienz
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Michelle Jane BurgerRobert Alexander Gardiner
Nov 13, 2002·The Journal of Cell Biology·Renee C IretonAlbert B Reynolds
Dec 21, 2002·Differentiation; Research in Biological Diversity·Molly A Thoreson, Albert B Reynolds
Nov 12, 2003·The Journal of Cell Biology·Michael A DavisAlbert B Reynolds
May 26, 2009·Molecules and Cells·Renato V IozzoAlexander Nyström

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Yingjie ShenKwonseop Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.