Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation

Genes & Development
D DohertyY N Jan

Abstract

Wing margin formation in Drosophila requires the Notch receptor and, in the dorsal compartment, one of its ligands, Serrate. We provide evidence that Delta, the other known ligand for Notch, is also essential for this process. Delta is required in ventral cells at the dorsal/ventral compartment boundary, where its expression is specifically elevated in second-instar wing discs during wing margin formation. Moreover, ectopic Delta expression induces wingless, vestigial, and cut and causes adult wing tissue outgrowth in the dorsal compartment. The effect is mediated by Notch, because loss of Notch activity suppresses Delta-induced ectopic wing outgrowth. Whereas ectopic expression of Notch or the truncated activated Notch induces cut in both dorsal and ventral compartments, ectopic Delta expression induces cut only in the dorsal compartment and ectopic Serrate induces cut only in the ventral compartment. These observations indicate that Notch-expressing cells in a given compartment have different responses to Delta and Serrate. We propose that Delta and Serrate function as compartment-specific signals in the wing disc, to activate Notch and induce downstream genes required for wing formation.

References

Sep 10, 1976·Science·V FrenchS V Bryant
Mar 22, 1991·Cell·P Heitzler, P Simpson
Sep 1, 1988·Trends in Neurosciences·J A Campos-Ortega
Mar 24, 1995·Cell·C E LindsellG Weinmaster
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
Apr 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S S Blair
Dec 1, 1994·Developmental Biology·J Klingensmith, R Nusse
Dec 1, 1994·Developmental Biology·M A Muskavitch
Sep 1, 1994·Mechanisms of Development·H K HingS Artavanis-Tsakonas
Feb 24, 1995·Cell·N Perrimon
May 1, 1994·Mechanisms of Development·J F de Celis, A García-Bellido
Oct 21, 1994·Cell·M E Fortini, S Artavanis-Tsakonas
Jun 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Siegfried, N Perrimon
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y N Jan, L Y Jan
Jan 22, 1993·Science·J P CousoA Martínez-Arias
Feb 26, 1993·Cell·G Struhl, K Basler
May 1, 1993·Genes & Development·A GhysenY N Jan
Jun 1, 1993·Developmental Biology·A L Parks, M A Muskavitch

❮ Previous
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Citations

Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N E Baker
Nov 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Cohen
Jan 6, 2006·Molecular Genetics and Genomics : MGG·Takashi J FuwaKenji Matsuno
Mar 22, 2003·Developmental Biology·Sabine L MazaleyratMartin Baron
Aug 4, 1999·Trends in Genetics : TIG·C Dahmann, K Basler
Jun 1, 1999·Mechanisms of Development·J C Rusconi, V Corbin
Jan 13, 1998·Current Opinion in Cell Biology·K D Irvine, T F Vogt
Sep 8, 1998·Current Opinion in Genetics & Development·G Weinmaster
Feb 28, 2002·Current Opinion in Neurobiology·Nicholas J Justice, Yuh Nung Jan
Oct 1, 1996·Current Opinion in Neurobiology·R Kopan, D L Turner
Feb 1, 1997·Current Opinion in Neurobiology·M VervoortA Ghysen
Oct 6, 1999·Current Opinion in Neurobiology·J Y Wu, Y Rao
Dec 15, 2010·Immunology and Cell Biology·Gerard F HoyneSally L Dunwoodie
Sep 2, 2008·Oncogene·B D'SouzaG Weinmaster
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·E FriseY N Jan
Oct 23, 2009·Molecular Biology of the Cell·Li-Fang ShyuWu-Min Deng
Dec 24, 2010·Genome Research·Lucy CherbasPeter Cherbas
Jan 1, 1996·Annual Review of Cell and Developmental Biology·W J BrookS M Cohen
Jan 1, 1997·Annual Review of Cell and Developmental Biology·J Kimble, P Simpson
Nov 1, 2001·Annual Review of Cell and Developmental Biology·K D Irvine, C Rauskolb
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Neal I Alcalay, Gregory B Vanden Heuvel
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chulan KwonDeepak Srivastava
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Baonza, A Garcia-Bellido
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ZengY N Jan

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