Delta neutrophil index as a promising prognostic marker in out of hospital cardiac arrest

PloS One
Ho Young YuneHahn Shick Lee

Abstract

The post-resuscitation phase after out-of-hospital cardiac arrest (OHCA) is characterised by a systemic inflammatory response (e.g., severe sepsis), for which the immature granulocyte count is a diagnostic marker. In this study we evaluated the prognostic significance of the delta neutrophil index (DNI), which is the difference in leukocyte subfractions as assessed by an automated blood cell analyser, for early mortality after OHCA. OHCA records from the emergency department cardiac arrest registry were retrospectively analysed. Patients who survived at least 24 h after return of spontaneous circulation were included in the analysis. We evaluated mortality and cerebral performance category scores at 30 days. A total of 83 patients with OHCA were included in the study. Our results showed that DNI >8.4% on day 1 (hazard ratio [HR], 3.227; 95% CI, 1.485-6.967; p = 0.001) and DNI >10.5% on day 2 (HR, 3.292; 95% CI, 1.662-6.519; p<0.001) were associated with increased 30-day mortality in patients with OHCA. Additionally, DNI >8.4% on day 1 (HR, 2.718; 95% CI, 1.508-4.899; p<0.001) and DNI >10.5% on day 2 (HR, 1.709; 95% CI, 1.051-2.778; p = 0.02) were associated with worse neurologic outcomes 30 days after OHCA. A higher DNI is a pr...Continue Reading

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Citations

May 13, 2017·American Journal of Reproductive Immunology : AJRI·Hee Young ChoJa-Young Kwon
Apr 16, 2019·Journal of Clinical Laboratory Analysis·Jae Seung Soh, Sang-Woo Lim
May 15, 2020·Acute and Critical Care·Myung Jin SongMoo Suk Park
Apr 30, 2019·Journal of the American Heart Association·Nguyen MaiMarc W Halterman
Jun 27, 2019·Journal of the American Heart Association·Sergey RyzhovDavid B Seder
Feb 28, 2020·Scientific Reports·Seo Hee YoonJong Gyun Ahn
Jul 16, 2017·The American Journal of Emergency Medicine·Taeyoung KongSung Phil Chung

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Methods Mentioned

BETA
blood drawn

Software Mentioned

SAS
ADVIA

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