PMID: 11907641Mar 22, 2002Paper

Delta opioid receptors inhibit vagal bradycardia in the sinoatrial node

Journal of Cardiovascular Pharmacology and Therapeutics
K E JacksonJ L Caffrey

Abstract

Methionine-enkephalin-arginine-phenylalanine (MEAP) is an endogenous opiate derived from the C-terminal sequence of the larger precursor molecule proenkephalin. This heptapeptide is abundant in the myocardium and has significant vagolytic activity when infused systemically. MEAP interrupted vagal bradycardia when it was delivered directly into the sinoatrial node by local microdialysis. This study was conducted to determine the opioid receptor responsible for the vagolytic effect of MEAP. Microdialysis probes were placed in the sinoatrial node of mongrel dogs and perfused at 5 microL/min. Increasing doses of MEAP were included in the nodal perfusate and approximately two thirds of the vagal bradycardia was inhibited with a maximal effect at 0.3 nmoles/microL and a half-maximal response near 0.1 nmoles/microL. When deltorphin II (a delta opioid receptor agonist) was infused into the sinoatrial node, more than 95% of the vagal bradycardia was eliminated at 0.3 nmoles/microL with the half-maximal response near 0.1 nmoles/microL, indicating that deltorphin II was more efficacious than MEAP. The maximal deltorphin II and MEAP effects were both similarly reversed by the paired infusion of increasing doses of the delta opiate receptor...Continue Reading

References

Jan 1, 1992·Journal of Molecular and Cellular Cardiology·B A BarronJ L Caffrey
Nov 1, 1987·European Heart Journal·T OpthofL N Bouman
Jan 1, 1984·Journal of Molecular and Cellular Cardiology·M A Masson-PévetL N Bouman
May 1, 1997·Journal of Molecular and Cellular Cardiology·J J SchultzG J Gross
Mar 29, 2001·Autonomic Neuroscience : Basic & Clinical·M FariasJ L Caffrey

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Citations

Dec 15, 2005·Heart, Lung & Circulation·Olivier W V van den BrinkSalvatore Pepe
Apr 24, 2014·The Journal of Physiology·Daniel W White, Peter B Raven
Apr 10, 2016·The Journal of Physiology·Beth A HabeckerCrystal M Ripplinger
Mar 8, 2011·Experimental Biology and Medicine·Matthew A BarlowJames L Caffrey
Jun 12, 2013·Skin Pharmacology and Physiology·L MelgaardL J Petersen
Jul 4, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shavsha DavisJames L Caffrey
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Martin FariasJames L Caffrey
Aug 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·M FariasJ L Caffrey
Jun 20, 2006·American Journal of Physiology. Heart and Circulatory Physiology·S H DeoJ L Caffrey
Jul 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Martin FariasJames L Caffrey
Sep 12, 2003·Experimental Biology and Medicine·Amber A StanfillJames L Caffrey
Mar 28, 2006·Experimental Biology and Medicine·Matthew A BarlowJames L Caffrey

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