PMID: 8597403Dec 29, 1995Paper

Delta-sleep-inducing peptide sequels in the mechanisms of resistance to emotional stress

Annals of the New York Academy of Sciences
K V SudakovE V Koplik

Abstract

The aim of this study is to investigate time-related changes in substance P (SP), beta-endorphin (BE), and corticosterone (CORT) levels due to DSIP aftereffects in the control and stress rats. Experiments were carried out on male Wistar and August rats. The SP and BE immunoreactivity in the hypothalamus and plasma samples was determined radioimmunologically. Blood CORT level was determined radioimmunologically. The rats were stressed at nighttime in special cages and tied by tails to the back side of the cage. The stress experiments were repeated for 12 hours for 5 days. There were 6 groups: 1. control animals, 2. stress animals, 3. rats that received DSIP in a dose of 60 nmol/kg one hour before decapitation, 4. rats in which DSIP was injected 24 hour before decapitation, 5. stressed rats in which DSIP was injected one hour before decapitation during the 5th exposure to stress, 6. stressed rats to which DSIP was injected 12 hours before the 5th exposure to stress, i.e., 24 hours before decapitation. Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in hypothalamus and blood plasma. This suggests that the long-term stress-coping effect of DSIP depends on considerable changes in the...Continue Reading

Citations

May 1, 1995·Neuroscience and Behavioral Physiology·L S Ul'yaninskii
Jan 29, 2000·Biulleten' eksperimental'noĭ biologii i meditsiny·M G PshennikovaI Iu Malyshev
Apr 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu B DeshevoĭR M Salieva
Apr 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·T G AnishchenkoL N Shorina
Nov 24, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·L M GershteĭnN N Bogolepov
Feb 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·K V Sudakov
Oct 18, 2000·Journal of Psychosomatic Research·R Maunder
Aug 12, 2014·Bulletin of Experimental Biology and Medicine·A V Sergutina, V I Rakhmanova
Sep 15, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Konstantin V. SudakovKirill S. Rayevsky
May 9, 2001·Stress : the International Journal on the Biology of Stress·A V Gorbunova
Jun 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·V V SerovK V Sulakov
Jul 5, 2001·European Journal of Anaesthesiology·B J Pollard, C J Pomfrett

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