Delta(9)-THC stimulates food intake in Lewis rats: effects on chow, high-fat and sweet high-fat diets

Pharmacology, Biochemistry, and Behavior
J E Koch

Abstract

Free-feeding adult male Lewis rats were administered intraperitoneal (i.p.) Delta(9)-tetrahydrocannabinol (THC) in doses of 0.5, 1.0 and 2.5 mg/kg, and effects on food intake were measured at 1, 2, 4, 6 and 24 h postinjection. Rats were fed rat chow, a high-fat diet (HF) or a high-fat sweetened (HFS) diet. Small increases in HF and HFS intake following doses of 0.5 or 1.0 mg/kg were seen at 1, 2 and 4 h, but not 6 or 24 h compared to vehicle intake. Increases following 0.5 and 1.0 mg/kg did not differ from each other at any time point and 2.5 mg/kg produced smaller differences at all time points. There was no difference between HF or HFS intake at any time point although larger increases were seen in the HF group compared to both chow and HFS following 0.5 and 1.0 mg/kg. This work confirms previous data in both humans and rats indicating a stimulatory role for cannabinoids in ingestive behavior.

References

May 1, 1976·Pharmacology, Biochemistry, and Behavior·R D Sofia, L C Knobloch
Jan 1, 1988·Psychopharmacology·E L GardnerD Morrison
Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·R W FoltinM W Fischman
Jul 1, 1974·Behavioral Biology·J P Gluck, D P Ferraro
Jul 1, 1973·Pharmacology, Biochemistry, and Behavior·P O SjödénB G Henriksson
Jan 1, 1980·Neuropharmacology·A K BhattacharyyaS N Pradhan
Jun 1, 1983·Journal of Clinical Psychopharmacology·H GrossN Zinberg
Feb 1, 1995·Behavioral Neuroscience·L A Parker, T Gillies
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·R D MattesM A Elsohly
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·R D MattesM A Elsohly
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·B A Gosnell, D D Krahn
Aug 6, 1998·Journal of Psychoactive Drugs·D I Abrams
Dec 17, 1998·Physiology & Behavior·C M WilliamsT C Kirkham
Mar 12, 1999·Physiology & Behavior·A M Altizer, T L Davidson
Jun 3, 1999·Psychopharmacology·C M Williams, T C Kirkham
Jul 27, 1999·Current Opinion in Chemical Biology·E Pop

❮ Previous
Next ❯

Citations

Apr 15, 2004·Psychopharmacology·Carla Sanchis-SeguraRainer Spanagel
Feb 24, 2006·Psychopharmacology·Gian Luigi GessaGiancarlo Colombo
May 20, 2009·Psychopharmacology·Maria Flavia BarbanoRafael Maldonado
Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Dan Zhou, Lauren P Shearman
Aug 9, 2002·European Journal of Pharmacology·Roberto CiccocioppoMaurizio Massi
Jun 5, 2002·Physiology & Behavior·Claire M Williams, Tim C Kirkham
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Claire M Williams, Tim C Kirkham
Jul 3, 2010·Journal of Medicinal Chemistry·Darryl D DixonAlexandros Makriyannis
Jul 15, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T M Fong, S B Heymsfield
Mar 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aaron N A VertyBrian J Oldfield
Jul 22, 2010·Annual Review of Nutrition·Mauro MaccarroneLuciana Avigliano
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Clare M MathesNeil E Rowland
Feb 26, 2010·Diabetology & Metabolic Syndrome·Eduardo Tibiriça
Sep 28, 2005·Journal of Addictive Diseases·Matthew WarrenMark Gold
Aug 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giovanni Hernandez, Joseph F Cheer
Sep 18, 2012·Frontiers in Neuroendocrinology·Kevin Sinchak, Edward J Wagner
Jun 26, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rahul R Deshmukh, P L Sharma
Mar 17, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R-A LevendalC L Frost
Sep 18, 2009·European Journal of Pharmacology·Brian A KellertEdward J Wagner
Mar 17, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Denis RichardElena Timofeeva
Aug 5, 2003·The Journal of Clinical Investigation·Daniela CotaUberto Pagotto
Oct 30, 2012·Pharmacology, Biochemistry, and Behavior·Lesley D O'BrienLinda A Parker
Jun 16, 2015·Pharmacology, Biochemistry, and Behavior·Mónica Méndez-DíazOscar Prospéro-García
Sep 6, 2011·Journal of Psychopharmacology·C M Olarte-SánchezA J Goudie
Feb 11, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C Ravinet TrillouP Soubrié
Nov 20, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Iain S McGregorJason E Gallate
Mar 22, 2005·British Journal of Pharmacology·Jenny L WileyBilly R Martin
Mar 12, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D CotaU Pagotto
Sep 27, 2005·Physiological Reviews·Sarah StanleyStephen Bloom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.