DeltaA mRNA and protein distribution in the zebrafish nervous system.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Alexandra TallafussJudith S Eisen

Abstract

Physical interaction between the transmembrane proteins Delta and Notch allows only a subset of neural precursors to become neurons, as well as regulating other aspects of neural development. To examine the localization of Delta protein during neural development, we generated an antibody specific to zebrafish Delta A (Dla). Here, we describe for the first time the subcellular localization of Dla protein in distinct puncta at cell cortex and/or membrane, supporting the function of Dla in direct cell-cell communication. In situ RNA hybridization and immunohistochemistry revealed dynamic, coordinated expression patterns of dla mRNA and Dla protein in the developing and adult zebrafish nervous system. Dla expression is mostly excluded from differentiated neurons and is maintained in putative precursor cells at least until larval stages. In the adult brain, dla mRNA and Dla protein are expressed in proliferative zones normally associated with stem cells.

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Citations

May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fadi A IssaDiane M Papazian
May 20, 2011·Developmental Neurobiology·Caghan KizilMichael Brand
Sep 3, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Carlene DyerRobert Knight
Dec 12, 2012·Journal of Neuroscience Methods·Shunren XiaWeiming Xia
Jun 8, 2017·Developmental Neurobiology·Surendra Kumar Anand, Amal Chandra Mondal
Jul 12, 2019·Scientific Reports·Priyanka SharmaMaximilian Fürthauer
Dec 24, 2021·Frontiers in Behavioral Neuroscience·John HageterEric J Horstick

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