Deltamethrin exposure induces oxidative stress and affects meiotic maturation in mouse oocyte

Chemosphere
Zhen-Zhen JiaXi-Zeng Feng

Abstract

Pyrethroid insecticides are commonly used as insecticides and considered to be less toxic to mammals, but may still impair the reproduction of animals and humans. The aim of this research was to evaluate the tendency of deltamethrin induced oxidative stress and its effects on meiosis, apoptosis and autophagy of mouse oocytes in vitro maturation after deltamethrin exposure. Especially, the maturation rate of oocytes decreased significantly after 14 h exposure of deltamethrin in concentration-dependent manners, which was manifested as abnormal spindle morphology and DNA double strand breaks. Oxidative stress was found in mouse oocytes exposed to deltamethrin, as shown by changes in the expression of CAT and SOD2. Our results also show that deltamethrin affects the quality of oocytes by causing abnormal mitochondrial distribution and by decreasing mitochondrial membrane potential. The apoptosis of oocyte regulated by the expression of Bax and Bcl-2 protein was obviously affected by deltamethrin. Compared with the control group, the expression of key regulatory factors in the autophagy pathway, LC3, Atg12, Atg14, and Beclin, increased in the experimental group. In summary, these results revealed that deltamethrin might inhibit the ...Continue Reading

Citations

Jan 4, 2020·Parasitology Research·Yuanyuan XiaMiao Liu
Jan 2, 2020·Antioxidants & Redox Signaling·Alexandra E PetersJessie M Sutherland
Apr 7, 2021·Critical Reviews in Toxicology·Anandha Rao Ravula, Suresh Yenugu
Sep 16, 2020·Ecotoxicology and Environmental Safety·Feifei ShiXizeng Feng
Jun 15, 2021·Journal of Cellular Physiology·Ling WangFenge Li
Apr 14, 2021·Animal Bioscience·Shi Bin ChengJin Song Pi
Jun 11, 2020·Ecotoxicology and Environmental Safety·Yu-Qing GaoCheng-Guang Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms