Delusions in Patients with Alzheimer's Disease: A Multidimensional Approach

Journal of Alzheimer's Disease : JAD
Grazia D'OnofrioAntonio Greco

Abstract

In Alzheimer's disease (AD) patients with delusions, clinical outcomes and mortality result from a combination of psychological, biological, functional, and environmental factors. We determined the effect of delusions on mortality risk, clinical outcomes linked to comprehensive geriatric assessment (CGA), cognitive, depressive, and neuropsychiatric symptoms (NPS) in 380 consecutive AD patients with Mini-Mental State Examination, Clinical Dementia Rating scale, 15-item Geriatric Depression Scale, and Neuropsychiatric Inventory (NPI), assessing one-year mortality risk using the Multidimensional Prognostic Index (MPI). We included 121 AD patients with delusions (AD-D) and 259 AD patients without delusions (AD-noD). AD-D patients were significantly older, with higher age at onset and cognitive impairment, a more severe stage of dementia, and more depressive symptoms than AD-noD patients. Disease duration was slightly higher in AD-D patients than in those without delusions, although this difference was not statistically significant. At CGA, AD-D patients showed a higher grade of disability in basic and instrumental activities of daily living, and an increased risk of malnutrition and bedsores. The two groups of patients significantl...Continue Reading

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Citations

Jan 24, 2019·Current Treatment Options in Neurology·Kasia Gustaw Rothenberg, Ryan Rajaram
Oct 13, 2017·International Journal of Geriatric Psychiatry·Leo LaiAmir A Sepehry
Feb 27, 2018·Journal of Alzheimer's Disease : JAD·Grazia D'OnofrioDavide Seripa
Jun 12, 2018·Journal of Alzheimer's Disease : JAD·Maria RuizGerard Piñol-Ripoll
Mar 12, 2019·International Psychogeriatrics·Milena AnatchkovaMyrlene Sanon Aigbogun
May 2, 2018·Journal of Alzheimer's Disease : JAD·Nicole CortésRicardo B Maccioni
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May 16, 2018·Neurología : publicación oficial de la Sociedad Española de Neurología·C JorgeG Piñol-Ripoll

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