Dementia as a complication of schizophrenia

Journal of Neurology, Neurosurgery, and Psychiatry
P J de VriesP J McKenna

Abstract

Cognitive impairment is known to occur in schizophrenia, and may be marked in institutionalised patients. The aim of this study was to determine whether it ever warrants an additional diagnosis of dementia. A population of chronic schizophrenic patients who were aged 65 or younger and showed no organic risk factors for dementia were screened for presence of disorientation. Any showing this underwent neuropsychological testing, physical investigations, and structural and functional neuroimaging. Information about day to day cognitive function was also obtained from carers. Eight patients aged 28 to 64 were identified who showed disorientation; in all cases this was accompanied by general intellectual impairment and objective evidence of a dementia syndrome. The patients' schizophrenic symptoms were unexceptional and did not seem sufficient to account for their cognitive impairment. Neuropsychological testing disclosed relative sparing of visual and visuospatial function and language syntax, but pervasive deficits in memory and executive function. Brain CT demonstrated only minor abnormalities but most of the patients showed frontal or temporal hypoperfusion on SPECT. Dementia in schizophrenia seems to be a real entity with a neu...Continue Reading

References

Apr 1, 1978·Acta Psychiatrica Scandinavica·E C JohnstoneJ Husband
Aug 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·M StevensE C Coles
Aug 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·T J Crow, M Stevens
Jun 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson, A O'Connell
Jun 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·T Shallice, M E Evans
Dec 1, 1976·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson
Sep 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·K W Brown, T White
Dec 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·D J King
Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Nov 1, 1990·Psychological Medicine·P J McKennaA D Baddeley
Sep 16, 1989·Lancet·M J de LeonD C Miller
Apr 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·N BuhrichD G Owens
Aug 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·T E GoldbergD R Weinberger
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Sep 1, 1987·Archives of Gerontology and Geriatrics·L Gustafson
Oct 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·A K Gopalaswamy, R Morgan
Feb 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·P F Liddle, T J Crow
Sep 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·E C JohnstoneJ F MacMillan
Apr 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·D G Cunningham Owens, E C Johnstone
Mar 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·P J Harrison
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·S E Chua, P J McKenna
Jun 3, 1995·Lancet·R C Gur, R E Gur
Feb 1, 1994·Archives of General Psychiatry·A J SaykinR C Gur
Apr 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·T M HydeJ E Kleinman
Jan 1, 1993·Schizophrenia Bulletin·T E GoldbergD R Weinberger
Jul 1, 1996·Comprehensive Psychiatry·M D Beer
Feb 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·E Y ChenD G Nguyen
Nov 16, 1996·Lancet·R F Duyff, H C Weinstein
Feb 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·R M NormanL Cortese
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·A M Mortimer
Dec 12, 1997·Acta Psychiatrica Scandinavica·G N SmithW G Honer
Dec 24, 1997·Psychological Medicine·A S DavidG Lewis
Aug 5, 1998·Schizophrenia Research·K NiizatoK Ikeda

❮ Previous
Next ❯

Citations

Apr 6, 2012·Der Nervenarzt·F U LangM Jäger
Aug 25, 2011·The Psychiatric Quarterly·Jharna N ShahPaul E Schulz
Jan 4, 2012·L'Encéphale·J-M AzorinE Fakra
Jan 13, 2006·Psychiatry and Clinical Neurosciences·Yurinosuke KitabayashiKenji Fukui
Sep 19, 2007·Psychiatry and Clinical Neurosciences·Yurinosuke KitabayashiKenji Fukui
Jul 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Delphine SchoderDominique Campion
Jul 6, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Jordi Ortiz-GilPeter J McKenna
Apr 25, 2013·International Review of Psychiatry·Michał HarciarekElkhonon Goldberg
Aug 3, 2007·International Review of Psychiatry·Serge A Mitelman, Monte S Buchsbaum
Feb 26, 2016·BMC Psychiatry·Anna MosiołekAgata Szulc
Jan 25, 2007·Neurourology and Urodynamics·Amardeep KumarShiva Prakash Srinivasan
Apr 9, 2014·The Australian and New Zealand Journal of Psychiatry·Hui-Minn ChanDennis Velakoulis
Jun 5, 2013·Journal of Geriatric Psychiatry and Neurology·Joseph J Cooper, Fred Ovsiew
Sep 19, 2002·Journal of Psychopharmacology·Andrew K HowardWilliam G Honer
Mar 23, 2018·Psychological Medicine·Osvaldo P AlmeidaLeon Flicker
Aug 2, 2002·Current Opinion in Neurology·Eric Salmon
Apr 1, 2007·Dementia & Neuropsychologia·Ricardo de Oliveira-SouzaJorge Moll
Aug 10, 2021·International Journal of Psychiatry in Clinical Practice·Carlo Lazzari, Marco Rabottini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.