Dementia Research: Populations, Progress, Problems, and Predictions

Journal of Alzheimer's Disease : JAD
Sally HunterCarol Brayne

Abstract

Alzheimer's disease (AD) is a clinicopathologically defined syndrome leading to cognitive impairment. Following the recent failures of amyloid-based randomized controlled trials to change the course of AD, there are growing calls for a re-evaluation of basic AD research. Epidemiology offers one approach to integrating the available evidence. Here we examine relationships between evidence from population-based, clinicopathological studies of brain aging and a range of hypotheses from all areas of AD research. We identify various problems, including a lack of systematic approach to measurement of clinical and neuropathological factors associated with dementia in experimental and clinical settings, poor understanding of the strengths and weaknesses of different observational and experimental designs, a lack of clarity in relation to disease definitions from the clinical, neuropathological, and molecular perspectives, inadequate characterization of brain aging in the human population, difficulties in translation between laboratory-based and population-based evidence bases, and a lack of communication between different sections of the dementia research community. Population studies highlight complexity and predict that therapeutic a...Continue Reading

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Citations

Apr 20, 2019·Mechanisms of Ageing and Development·Kenneth Rockwood, Susan E Howlett
Jun 3, 2021·Journal of Personalized Medicine·Stefania ZampattiEmiliano Giardina
Jun 14, 2021·Frontiers in Neuroendocrinology·C SzoekeS Phillips

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