Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research

Alzheimer's Research & Therapy
Craig W RitchieTerence J Quinn

Abstract

Dementia is a substantial and increasing public health concern. Despite decades of research, a cure or effective preventative treatment for dementia remains elusive. We offer critical review of contemporary dementia research and discuss potential reasons why progress in the field has not been as rapid as in other disciplines. We adopt a broad approach in keeping with the broad nature of the topic. We cover the difficulties inherent in studying dementia from 'bench' to 'bedside' to 'population'. We make particular reference to issues of operationalisation of the dementia syndrome and our evolving understanding of dementia as a research 'outcome'. We discuss contemporary 'hot topics' in dementia research methodology focussing on dementia models, pre-dementia states and biomarkers. Recognising the importance of prospective epidemiological cohorts and large-scale clinical trials we pay particular attention to these approaches and the challenges of generating results that have 'real world' external validity. Based on our thoughts we end with suggestions for future dementia research. Our review is designed to be critical but not unnecessarily negative. There is reason for cautious optimism in dementia research. The recent G8 summit o...Continue Reading

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Citations

Apr 16, 2016·Journal of Alzheimer's Disease : JAD·Carsten HennegesJeremie Lebrec
Mar 13, 2018·Age and Ageing·Yemisi Takwoingi, Terence J Quinn
Feb 6, 2017·Stroke; a Journal of Cerebral Circulation·Rachael L MacIsaacUNKNOWN VISTA Collaborators
Feb 28, 2019·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Julie WatsonCharlotte Clarke
Feb 12, 2019·Journal of Alzheimer's Disease : JAD·Anna BebeFrans Boch Waldorff
Jul 16, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Fatima IqbalDemidmaa Tuvdendorj
Jan 16, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jenny McCleeryTerence J Quinn
May 22, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shirin SalimiJames R Burrell
Nov 11, 2016·Medicine, Health Care, and Philosophy·Karin Rolanda Jongsma, Martin Sand
Aug 28, 2020·Frontiers in Neurology·Sophie Amelia EdwardsTerence J Quinn
Jan 18, 2017·BMC Medicine·Milija D MijajlovićNatan M Bornstein
Oct 5, 2016·Journal of Public Health·S MitchellM Norton
Sep 15, 2019·The Cochrane Database of Systematic Reviews·Calvin Ch ChanDallas P Seitz
Mar 11, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Aisling McFallTerence J Quinn
Jun 4, 2021·Frontiers in Artificial Intelligence·Graciela Muniz-TerreraMichael D Lesh
Jun 14, 2021·Frontiers in Neuroendocrinology·C SzoekeS Phillips
Jul 15, 2021·The Cochrane Database of Systematic Reviews·Calvin Ch ChanDallas P Seitz
Sep 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Terence J QuinnHugh S Markus

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Methods Mentioned

BETA
genotyping

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