PMID: 9169566Jun 1, 1997Paper

Dementia with lewy bodies: a study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon emission tomography

European Journal of Nuclear Medicine
Z WalkerC L E Katona

Abstract

Dementia with Lewy bodies (DLB) can at present only be diagnosed with certainty by neuropathological examination. Diagnosis during life remains at best probable, based on the presence of symptoms known from autopsy studies to be frequently associated with DLB. The greatest practical clinical problem lies in distinguishing DLB and Alzheimer's disease (AD). In DLB there is a considerable degeneration of nigral neurones with depletion of striatal dopamine. In contrast, AD is not associated with significant changes in dopamine metabolism. Iodine-123 iodobenzamide single-photon emission tomography (IBZM-SPET) measures post-synaptic dopamine D2 neuroreceptor availability in the corpus striatum, but is nevertheless a method for assessing the integrity of the nigrostriatal dopaminergic pathway. Sixteen clinically diagnosed DLB patients, 15 normal controls and 13 AD patients underwent IBZM-SPET. All subjects were scanned 1.5-2 h after intravenous injection of 185 MBq of 123I-IBZM. Circular regions of interest were employed to calculate radioactivity ratios in each hemisphere as follows: caudate nucleus/frontal cortex, putamen/frontal cortex and caudate nucleus/putamen. The DLB patients had significantly lower left caudate/putamen ratios...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BrückeL Deecke
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·U K RinneU Ruotsalainen
Jan 1, 1990·European Journal of Nuclear Medicine·D C CostaM Bobeldijk
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·E J ByrneR B Godwin-Austen
Nov 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·G LennoxR B Godwin-Austen
Sep 1, 1981·The British Journal of Clinical Psychology·A H Pattie
Apr 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·J O RinneU Ruotsalainen
May 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·M A HelyJ G Morris
Dec 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·I G McKeithE J Byrne

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Citations

Jan 25, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Klaus Tatsch
Aug 25, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Claudia Metzler-Baddeley
Oct 6, 1999·Lancet·D C CostaP J Ell
Mar 14, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Zuzana WalkerCornelius L E Katona
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Z WalkerC L E Katona
May 1, 2008·The British Journal of Radiology·S L Pimlott, K P Ebmeier
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Dec 22, 2015·Seminars in Nuclear Medicine·Laura B EisenmengerJames M Mountz
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew H EvansAndrew J Lees
Apr 3, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sabina PappatàAlfredo Postiglione
Dec 19, 2001·International Journal of Geriatric Psychiatry·R BarberI G McKeith
Feb 17, 1998·The British Journal of Psychiatry : the Journal of Mental Science·R L AllenC L Katona
Jan 5, 2000·The Australian and New Zealand Journal of Psychiatry·I McKeith, J O'Brien
Aug 24, 2011·International Psychogeriatrics·Zuzana Walker, Joanne Rodda

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