Demineralized Dentin as a Semi-Rigid Barrier for Guiding Periodontal Tissue Regeneration

Journal of Periodontology
Xu QinBin Zhou

Abstract

Guided tissue regeneration (GTR) is an accepted approach in the correction of periodontal bone loss. Nonetheless, the deficiencies of commonly applied absorbable membrane, such as flexibility and limited osteoconductive and osteoinductive capability, still leave much room for improvement. Thus, the feasibility of applying demineralized dentin tissue to improve the therapeutic effect of GTR in periodontal regeneration was explored. Demineralized dentin was harvested after acid treatment, and its physiochemical properties were assessed in terms of mineralization density, contact angle, three-point test, and cell attachment. Because of its similar characteristics with bone tissue, dentin that had been acid-treated for 6 hours was chosen to repair a periodontal defect using an induced-periodontitis canine model. Histologic measurements were taken to compare its therapeutic effects to an absorbable membrane group and an untreated group. The demineralized dentin displayed continually decreased hardness and density as the acid etching time was prolonged. Enhanced attachment and spreading of bone marrow mesenchymal stem cells were observed on the 6-hour processed dentin. Furthermore, in the demineralized dentin group, more periodontal ...Continue Reading

References

Jan 1, 1995·Connective Tissue Research·W T Butler
Jun 28, 2005·Dental Clinics of North America·Dimitris N Tatakis, Purnima S Kumar
Nov 2, 2005·Tissue Engineering·Conan S YoungPamela C Yelick
Mar 14, 2007·Dental Materials : Official Publication of the Academy of Dental Materials·Sarah L RollandJohn F McCabe
Jan 1, 2008·Journal of the Mechanical Behavior of Biomedical Materials·J J Kruzic, R O Ritchie
Jan 12, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Young-Kyun KimSuk-Young Kim
Nov 18, 2010·Journal of Periodontology·Maurizio SilvestriStefano Milani
Sep 3, 2011·Biomaterials·Emily C Carlo ReisJohn E Davies
Nov 23, 2011·Journal of Nanoscience and Nanotechnology·Young-Kyun KimSoo-Young Lim
Jan 4, 2012·Journal of Biomedical Materials Research. Part a·Masaru MurataMakoto Arisue
Apr 21, 2012·Journal of Endodontics·Allen N SawyerFranklin R Tay
May 18, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Marco C BottinoGregg M Janowski
Sep 4, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Young-Kyun KimGyung-Wook Kim
Apr 12, 2013·Periodontology 2000·Jørgen Slots
Jul 16, 2013·Journal of Biomaterials Science. Polymer Edition·Jianan LiGuanxin Shen
Sep 26, 2013·The International Journal of Oral & Maxillofacial Implants·Veronika PivodovaJitka Ulrichova
Nov 28, 2013·The International Journal of Oral & Maxillofacial Implants·Neema BakhshalianBahram H Arjmandi
Dec 7, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Ana K Bedran-RussoAriene A Leme
Jan 29, 2014·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Young-Kyun KimMasaharu Mitsugi
Mar 7, 2014·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Xu QinBin Zhou
Apr 1, 2014·The International Journal of Oral & Maxillofacial Implants·Basim K AtiyaHa Oon
May 9, 2014·International Journal of Oral Science·Rui-Rui LiuJi-Hua Chen
Aug 21, 2014·Journal of Dental Research·S IvanovskiP M Bartold
Apr 14, 2015·Periodontology 2000·Anton SculeanAndreas Stavropoulos

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