Demographic and Clinical Correlates of Mucosal Disaccharidase Deficiencies in Children With Functional Dyspepsia

Journal of Pediatric Gastroenterology and Nutrition
Bruno P ChumpitaziMark A Gilger

Abstract

A subset of children with functional gastrointestinal disorders (FGIDs), which includes functional dyspepsia, may have duodenal disaccharidase deficiencies. To determine the frequency, demographics, and clinical characteristics associated with duodenal disaccharidase deficiencies in children with functional dyspepsia. Children ages 4 to 18 years undergoing esophagogastroduodenoscopy (EGD) evaluation for dyspepsia were enrolled in either a retrospective (study 1) or prospective (study 2) evaluation. Those with histologic abnormalities were excluded. Duodenal biopsies were obtained for disaccharidase enzyme analysis. In the retrospective study, both demographic and clinical characteristics were obtained via chart review. In the prospective study, parents completed the Rome II Questionnaire on Gastrointestinal Symptoms before the EGD. One hundred and twenty-nine children (n = 101, study 1; n = 28, study 2) were included. Mean age was 11.2 ± 3.8 (SD) years in study 1 and 10.6 ± 3.2 years in study 2. Forty-eight (47.5%) of subjects in study 1 and 13 (46.4%) of subjects in study 2 had at least 1 disaccharidase deficiency identified. All of those with a disaccharidase deficiency in both studies had lactase deficiency with 8 (7.9%) and...Continue Reading

References

Jun 28, 1979·The New England Journal of Medicine·R G BarrJ B Watkins
Aug 1, 1996·The American Journal of Clinical Nutrition·S R Hertzler, D A Savaiano
Feb 5, 1999·Journal of Pediatric Gastroenterology and Nutrition·W R TreemJ Hyams
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Marian D PfefferkornJean P Molleston
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Wikrom KarnsakulBuford Nichols
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsErwin E Sterchi
Apr 2, 2003·Annual Review of Public Health·Vickie M MaysSusan D Cochran
Jan 1, 1964·Analytical Biochemistry·A DAHLQVIST
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsSusan S Baker
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Bruno P ChumpitaziHassan Y Naim
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Klaus-Peter ZimmerHassan Y Naim
Aug 2, 2013·Nature·Andrew Curry
Oct 2, 2013·Journal of the National Medical Association·Rahn K BaileySharon Denise Allison-Ottey
May 21, 2015·PloS One·Judith J KorterinkMerit M Tabbers
Jul 15, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Khalil El-ChammasAdrian Miranda
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Taylor DailedaKalpesh Thakkar
Jun 30, 2016·Annals of Nutrition & Metabolism·Bruno P Chumpitazi, Robert J Shulman
May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsRoberto Quezada-Calvillo

❮ Previous
Next ❯

Citations

May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Buford Nichols, William J Klish
Aug 1, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chirajyoti DebDevendra I Mehta
Aug 17, 2021·Pediatric Health, Medicine and Therapeutics·Craig FriesenJennifer V Schurman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.