Demographic and clinical features distinguish subgroups of diverticular disease patients: Results from an Italian nationwide registry

United European Gastroenterology Journal
Marilia CarabottiBruno Annibale

Abstract

Clinical features and lifestyle factors associated with diverticulosis compared to diverticular disease (DD), either symptomatic uncomplicated diverticular disease (SUDD) or in patients who have had previous diverticulitis (PD), are unclear. The objective of this article is to compare cross-sectionally demographic and clinical features and quality of life (QoL) in diverticulosis, SUDD and PD patients. The REMAD Registry is a prospective, observational, multicentre, cohort study. Patients were categorised according to: diverticulosis; SUDD (recurrent abdominal symptoms attributed to diverticula in absence of overt inflammation) and PD (≥1 previous diverticulitis). A total of 1217 patients (57.9% diverticulosis, 24.7% SUDD and 17.4% PD) were included. Compared to diverticulosis, female gender was associated to SUDD (OR 1.94; 95% CI: 1.43-2.62) and PD (OR 1.79; 95% CI: 1.24-2.56); age ≤ 60 years was associated to PD (OR 2.10; 95% CI: 1.42-3.08 vs diverticulosis, OR 1.57; 95% CI: 1.01-2.45 vs SUDD). PD patients showed an association with past bleeding (OR 29.29; 95% CI: 8.17-104.98 vs diverticulosis, OR 16.84; 95% CI: 3.77-75.25 vs SUDD). Compared to diverticulosis, family history for diverticula was associated to PD (OR 1.88; 95% ...Continue Reading

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Citations

Jul 22, 2018·F1000Research·Carola SeveriBruno Annibale
Jul 27, 2018·Therapeutic Advances in Gastroenterology·Angel LanasAitor Lanas-Gimeno
Jul 19, 2019·United European Gastroenterology Journal·Cesare CremonGiovanni Barbara
Jun 20, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Marilia CarabottiUNKNOWN REMAD group
Apr 20, 2021·European Journal of Gastroenterology & Hepatology·Antonio TursiGiovanni Brandimarte

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