Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Head and Neck Pathology
Faraj M AlotaibyI Bhattacharyya

Abstract

Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Extraoral cases as well as cases with insufficient patient information were excluded. A total of 340 out of 164,578 submitted specimens in a 22 year period (0.2%) were included with a mean age of 43.3 years (range: 6-89), and 44% male and 56% female. The most commonly affected locations were: tongue (37.5%), palate (22%), lip (19%), and gingiva (14%). The microscopic diagnoses rendered, in descending order of frequency were: neurofibromas (NFs): 123 (36%), granular cell tumor (GCT): 108 (32%), schwannomas: 61 (17%), palisaded encapsulated neuromas: 39 (11%), benign neural lesion not otherwise specified: 8 (2%), and mucosal neuroma c/w multiple endocrine neoplasia type 2B (MEN 2B): 1 (< 0.5%). Six cases of NF reported a history of neurofibromatosis Type 1 (NF 1). Four cases showed multifocal lesions. Immunohistochemical staining was performed on e...Continue Reading

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Citations

Sep 6, 2019·Head and Neck Pathology·Lester D R ThompsonSean K Lau
Sep 10, 2019·International Journal of Surgical Pathology·Maria Eduarda Pérez-De-OliveiraPablo Agustin Vargas
Oct 23, 2020·Head and Neck Pathology·Bruno Augusto Linhares Almeida MarizRoman Carlos
Jan 18, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Alaa F BukhariMark A Lerman
Apr 4, 2021·Medicina·Saverio CapodiferroGianfranco Favia
May 11, 2021·International Journal of Surgery Case Reports·Ibtissam KissamiNabila Ismaili
Nov 7, 2020·Indian Journal of Pathology & Microbiology·Agnes AssaoDenise T Oliveira

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