Demographic confounders in volumetric MRI analysis: is the posterior fossa really small in the adult Chiari 1 malformation?

AJR. American Journal of Roentgenology
Lauren A RollerAmit M Saindane

Abstract

Measurement of posterior fossa volume has been proposed to have diagnostic utility and physiologic significance in the Chiari malformation type 1. This study evaluated the effects of demographics on posterior fossa volume and total intracranial volume in adult control subjects, adult patients with Chiari malformation type 1, and adult patients with idiopathic intracranial hypertension, who may share some imaging features of patients with Chiari malformation type 1. Twenty-eight patients with Chiari malformation type 1, 21 patients with idiopathic intracranial hypertension, and 113 control subjects underwent brain MRI including contrast-enhanced 3D gradient-recalled echo (GRE) T1-weighted imaging. Linear measurements of the posterior fossa and intracranial space were obtained. Manual segmentation of the posterior fossa and intracranial space was performed to yield posterior fossa volume and total intracranial volume. Age, sex, race, and body mass index (weight in kilograms divided by the square of height in meters; BMI) were controlled for when comparing cohorts. Three of the 12 linear measurements significantly predicted total intracranial volume (accounting for 74% of variance), and four predicted posterior fossa volume (54% o...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Nov 29, 2002·Neurology·Deborah I Friedman, Daniel M Jacobson
Mar 21, 2006·NeuroImage·Nicola PannacciulliPietro A Tataranni
May 10, 2006·Journal of the Neurological Sciences·Rudrani BanikNeil R Miller
Jul 28, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·T TrigylidasE C G Ventureyra
Oct 15, 2008·The International Journal of Neuroscience·John GunstadEvian Gordon
Sep 9, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sunil V FurtadoA S Hegde
Jul 20, 2010·Neurologic Clinics·Michael Wall
Apr 26, 2011·Neurological Research·Timothy M George, Nicole H Higginbotham
Jan 18, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Aintzane UrbizuAlfons Macaya
Mar 16, 2013·AJNR. American Journal of Neuroradiology·A M BagciN Alperin

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Citations

Oct 13, 2015·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Samuel BidotValérie Biousse
Oct 8, 2016·Neuroimaging Clinics of North America·Robert Y Shih, James G Smirniotopoulos
Jun 19, 2019·The Neuroradiology Journal·James R HoustonFrancis Loth
Oct 28, 2019·Acta neurochirurgica·Radek Frič, Per Kristian Eide
Jul 1, 2020·Neurosurgical Review·Veysel BuruldayAdnan Özdemir
Dec 12, 2018·Annals of Biomedical Engineering·Dipankar BiswasFrancis Loth
Sep 13, 2019·World Neurosurgery·Scott C SeamanBrian J Dlouhy
Jun 26, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Federico BianchiLuca Massimi

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