Demographic factors that influence human disc cell proliferation in vitro

The Spine Journal : Official Journal of the North American Spine Society
Helen E GruberEdward N Hanley

Abstract

Although previous work has shown that greater age, greater disc degeneration, female gender, and surgical derivation of disc tissue had deleterious effects on cell proliferative potential, relatively little is known about the association between disc cell proliferation in vitro and clinical donor characteristics. To identify the relationships between donor characteristic and the in vitro proliferative potential of human disc cells from the annulus. Studies were approved by the human subjects Institutional Review Board. Donor data included donor source, ethnicity, age, gender, smoking history, height, weight, number of years of back pain, and Thompson score. Cells cultured from the annulus were tested for proliferation. There were two study populations: 1) Comparison Group (32 control donors and 33 control surgical subjects; 60 Caucasians, 5 African-Americans). Cell proliferation, age, Thompson score, height, weight, and smoking history were statistically analyzed for control donors versus control surgical group. No significant differences were present, and these two groups were pooled to form the Comparison Group. 2) Nineteen subjects from the United Arab Emirates who underwent disc surgery. Linear models were fit to the data t...Continue Reading

References

Mar 21, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·H E GruberE N Hanley
Dec 18, 2007·The Spine Journal : Official Journal of the North American Spine Society·Satoshi SobajimaJames D Kang

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Citations

Jul 18, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Eijiro OkadaTakeshi Takahata
Jul 24, 2010·The Spine Journal : Official Journal of the North American Spine Society·Helen E GruberEdward N Hanley
Sep 18, 2007·Ageing Research Reviews·Chang-Qing ZhaoLi-Yang Dai

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