PMID: 11332668May 3, 2001Paper

Demographic rather than behavioral risk factors predict herpes simplex virus type 2 infection in sexually active adolescents

The Pediatric Infectious Disease Journal
G SucatoA Wald

Abstract

Despite the high prevalence of herpes simplex virus type 2 (HSV-2) infection in adults and data indicating that many HSV-2 infections are acquired in late adolescence, the demographic and sexual behavior correlates of HSV-2 infection in high risk adolescents have not been extensively studied. Using a cross-sectional design we evaluated serologic evidence of HSV-2 infection in 381 adolescents age 14 to 19 years at an urban sexually transmitted disease clinic and a community clinic. Study enrollment was offered to all patients participating in a project offering free hepatitis B vaccine. Participants were interviewed and blood was drawn for HSV Western blot. Twelve percent [95% confidence interval (CI), 8.6 to 15.1] of 379 adolescents in this study had antibodies to HSV-2. Only 22% of HSV-2-seropositive youth reported a history of herpes. Seropositivity for HSV-2 was significantly associated with African-American race (odds ratio, 2.3; 95% CI 1.1 to 4.8) and female gender (odds ratio, 6.0; 95% CI 2.3 to 15.9); 25% of the African-American girls were HSV-2-seropositive. Self-reported condom use, number of sexual partners in the prior 2 months and history of a sexually transmitted disease did not predict HSV-2 antibody status. HSV-2...Continue Reading

References

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Citations

Jul 15, 2009·Archives of Internal Medicine·Emily T MartinAnna Wald
Jan 29, 2005·Current Treatment Options in Neurology·James F Bale, Lonnie J Miner
Feb 27, 2003·Journal of Pediatric and Adolescent Gynecology·Richard A CrosbyEve Rose
Sep 28, 2002·The Journal of Infectious Diseases·Jennifer S Smith, N Jamie Robinson
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lawrence R StanberryDavid I Bernstein
Jul 3, 2003·Sexually Transmitted Diseases·Charles Dimitry AbrahamEduardo Lazcano-Ponce
Feb 3, 2005·Seminars in Pediatric Infectious Diseases·Beth A AuslanderSusan L Rosenthal
Mar 6, 2003·Neurologic Clinics·James F Bale
May 8, 2002·Paediatric Drugs·Lawrence R Stanberry, Susan L Rosenthal

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