Demographic trends in the incidence of young-onset colorectal cancer: a population-based study.

The British Journal of Surgery
A C ChambersD E Messenger

Abstract

Evidence is emerging that the incidence of colorectal cancer is increasing in young adults, but the descriptive epidemiology required to better understand these trends is currently lacking. A population-based cohort study was carried out including all adults aged 20-49 years diagnosed with colorectal cancer in England between 1974 and 2015. Data were extracted from the National Cancer Registration and Analysis Service database using ICD-9/10 codes for colorectal cancer. Temporal trends in age-specific incidence rates according to sex, anatomical subsite, index of multiple deprivation quintile and geographical region were analysed using Joinpoint regression. A total of 56 134 new diagnoses of colorectal cancer were analysed. The most sustained increase in incidence rate was in the group aged 20-29 years, which was mainly driven by a rise in distal tumours. The magnitude of incident rate increases was similar in both sexes and across Index of Multiple Deprivation quintiles, although the most pronounced increases in incidence occurred in the southern regions of England. Colorectal cancer should no longer be considered a disease of older people. Changes in incidence rates should be used to inform future screening policy, preventati...Continue Reading

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Citations

Mar 19, 2020·The British Journal of Surgery·Q Denost
Apr 28, 2020·The British Journal of Surgery·G Pellino
Sep 15, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A C ChambersD E Messenger
Jun 17, 2020·The British Journal of Surgery·G Pellino Editor Assistant
Jan 23, 2021·Expert Review of Gastroenterology & Hepatology·Obaida DairiLynn F Butterly
Mar 13, 2021·The British Journal of Surgery·C A FlemingC B Peirce
Nov 4, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Antonio V SterpettiPaolo Sapienza
Jul 1, 2021·JAMA Surgery·UNKNOWN REACCT CollaborativeDes C Winter
Jul 10, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Nigel D'SouzaUNKNOWN NICE FIT Steering Group
Aug 18, 2021·American Journal of Surgery·Swetha PrabhakaranPeter Carne
Aug 21, 2021·Annals of the Royal College of Surgeons of England·L NewtonJ Shabbir
Sep 17, 2021·BMJ : British Medical Journal·Priyanka Kanth, John M Inadomi

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Software Mentioned

Joinpoint Regression Program
Joinpoint

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