Demographics and characterization of 10,282 Randall plaque-related kidney stones: a new epidemic?

Medicine
Emmanuel LetavernierMichel Daudon

Abstract

Renal stone incidence has progressively increased in industrialized countries, but the implication of Randall plaque in this epidemic remains unknown. Our objectives were to determine whether the prevalence of Randall plaque-related stones increased during the past decades after having analyzed 30,149 intact stones containing mainly calcium oxalate since 1989 (cross-sectional study), and to identify determinants associated with Randall plaque-related stones in patients (case-control study). The proportion of Randall plaque-related stones was assessed over 3 time periods: 1989-1991, 1999-2001, and 2009-2011. Moreover, we analyzed clinical and biochemical parameters of 105 patients affected by calcium oxalate stones, with or without plaque. Of 30,149 calcium oxalate stones, 10,282 harbored Randall plaque residues (34.1%). The prevalence of Randall plaque-related stones increased dramatically during the past years. In young women, 17% of calcium oxalate stones were associated with Randall plaque during the 1989-1991 period, but the proportion rose to 59% 20 years later (P < 0.001). Patients with plaques experienced their first stone-related event earlier in life as compared with those without plaque (median age 26 vs 34 years, P =...Continue Reading

References

Dec 1, 1992·Medical Hypotheses·S Ohman, L Larsson
Aug 1, 1990·The Journal of Pediatrics·D M Curtis
Jan 11, 2002·The New England Journal of Medicine·Loris BorghiAlmerico Novarini
Mar 6, 2003·The Journal of Clinical Investigation·Andrew P EvanMarc Grynpas
Apr 5, 2003·Kidney International·Kiriaki K StamatelouGary C Curhan
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Richard R HoopesSteven J Scheinman
Nov 25, 2003·Kidney International·Ramsay L KuoFredric L Coe
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Murray J FavusFredric L Coe
Feb 16, 2005·The Journal of Urology·Margaret S PearleUNKNOWN Urologic Diseases of America Project
Jan 24, 2006·Annales D'urologie·M Daudon
Jan 28, 2006·Urological Research·Alberto Trinchieri
Feb 17, 2006·The New England Journal of Medicine·Rebecca D JacksonUNKNOWN Women's Health Initiative Investigators
Jun 1, 1937·Annals of Surgery·A Randall
Mar 25, 2008·Seminars in Nephrology·Elaine M Worcester, Fredric L Coe
Aug 22, 2008·American Journal of Physiology. Renal Physiology·Elaine M WorcesterDaniel L Gillen
Mar 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Emmanuel LetavernierJean-Philippe Haymann
Jan 25, 2013·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky
Oct 8, 2013·BMC Medical Genetics·Pan ZhangHong Jiang
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Philippe AutierPatrick Mullie
Apr 26, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Viviane Barcellos MenonIta Pfeferman Heilberg

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Citations

Jan 1, 2016·Urology·Arnaud DessombzMichel Daudon
Jun 15, 2016·Journal of the American Society of Nephrology : JASN·Kazumi TaguchiTakahiro Yasui
Jul 28, 2016·Nature Reviews. Nephrology·Fredric L CoeAndrew P Evan
Oct 25, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·D BazinM Daudon
Oct 13, 2016·Scientific Reports·Kazumi TaguchiTakahiro Yasui
Jan 19, 2018·International Urology and Nephrology·Armando Luis Negri
Apr 27, 2018·Current Opinion in Nephrology and Hypertension·Scott V WienerMarshall L Stoller
Jun 30, 2018·Current Opinion in Urology·Julian VeserChristian Seitz
Oct 19, 2016·The Journal of Urology·Cécile VerrierEmmanuel Letavernier
Feb 23, 2019·Journal of Endourology·Michael S BorofskyJames E Lingeman
Jul 12, 2018·Journal of the American Society of Nephrology : JASN·Emmanuel LetavernierLudovic Martin
May 11, 2018·Connective Tissue Research·Scott V WienerSunita P Ho
Mar 23, 2018·Nutrients·Emmanuel Letavernier, Michel Daudon
Mar 10, 2020·The Journal of Clinical Investigation·Joshua N CurryAlan Sl Yu
Jan 27, 2019·Journal of Nephrology·Agnieszka PozdzikKhashayar Sakhaee
Dec 22, 2019·International Journal of Molecular Sciences·Emmanuel LetavernierMichel Daudon
Dec 4, 2016·Urolithiasis·James C WilliamsJames E Lingeman
Jan 31, 2021·Nature Reviews. Nephrology·Saeed R KhanPaul R Dominguez-Gutierrez
Feb 13, 2018·Acta Biomaterialia·Benjamin A ShererSunita P Ho
Mar 4, 2020·Néphrologie & thérapeutique·Marie CourbebaisseMichel Daudon

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Methods Mentioned

BETA
infrared spectroscopy
urine collection
hormone replacement therapy
DNA collection

Software Mentioned

StatView
number cruncher statistical system ( NCSS )

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