Demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma: a UK population study

BJOG : an International Journal of Obstetrics and Gynaecology
P SavageM J Seckl

Abstract

To investigate the demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma. A retrospective national population-based study. UK 1995-2015. A total of 234 women with a diagnosis of gestational choriocarcinoma, in the absence of a prior molar pregnancy, managed at the UKs two gestational trophoblast centres in London and Sheffield. Retrospective review of the patient's demographic and clinical data. Comparison with contemporary UK birth and pregnancy statistics. Incidence statistics for non-molar choriocarcinoma across the maternal age groups. Cure rates for patients by FIGO prognostic score group. Over the 21-year study period, there were 234 cases of non-molar gestational choriocarcinoma, giving an incidence of 1:66 775 relative to live births and 1:84 226 to viable pregnancies. For women aged under 20, the incidence relative to viable pregnancies was 1:223 494, for ages 30-34, 1:80 227, and for ages 40-45, 1:41 718. Treatment outcomes indicated an overall 94.4% cure rate. Divided by FIGO prognostic groups, the cure rates were low-risk group 100%, high-risk group 96% and ultra-high-risk group 80.5%. Non-molar gestational choriocarcinoma is a very rare diagnosis with little prior detailed in...Continue Reading

References

Aug 18, 1977·Nature·T Kajii, K Ohama
Apr 1, 1986·American Journal of Obstetrics and Gynecology·H K AtrashD A Grimes
Sep 1, 1995·British Journal of Obstetrics and Gynaecology·J A TidyP Rowden
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
Jul 13, 2000·Lancet·M J SecklE S Newlands
Nov 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·R HERTZD B SPENCER
Jun 23, 2006·Gynecologic Oncology·Christianne A LokMarianne J ten Kate-Booij
Oct 19, 2007·Gynecologic Oncology·Rosemary A FisherMichael J Seckl
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Aug 13, 2011·BMJ : British Medical Journal·C AlifrangisM J Seckl
Oct 27, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C LybolP B Ottevanger
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Constantine AlifrangisMichael J Seckl
May 10, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P M SavageM J Seckl
Dec 17, 2014·Genetics and Molecular Research : GMR·Z Y ZhangX Y Lu
Oct 4, 2015·American Journal of Obstetrics and Gynecology·Pierre-Adrien BolzeFrançois Golfier
Mar 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Akram M ShaabanChristine O Menias

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