Demonstrating strategies for initiation of insulin therapy: matching the right insulin to the right patient

International Journal of Clinical Practice
L Meneghini

Abstract

To increase awareness regarding the different types of insulin available and provide discussion regarding how each type of insulin can address the needs of diverse patients in terms of their unique requirements, preferences, medical history and lifestyle concerns. New classes of antidiabetes medications, the development of insulin analogues and novel insulin delivery systems, provide more options for the management of type 2 diabetes. Given the inevitable progression of beta-cell dysfunction, along with the relatively limited glucose-lowering capacity of other agents, many patients will eventually require insulin for optimal glycaemic management. However, patients and physicians often fail to initiate insulin early enough during the progression of disease to maintain the recommended levels of glycaemic control. The inherent properties of the new insulin analogues, more physiological and user-friendly time-action profiles compared with older human insulin formulations, may partly address the barriers to insulin use. Insulin analogues include rapid acting (for prandial glycaemic control), long acting (for basal insulin coverage) and premixed insulin analogues, which combine both a rapid acting and an extended duration component i...Continue Reading

References

Mar 31, 1999·Diabetes Care·V A KoivistoP Ebeling
May 25, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·B O BoehmA Lindholm
Aug 26, 1961·Nature·S WILSON, G H DIXON
Oct 28, 2003·Diabetes Care·Matthew C RiddleUNKNOWN Insulin Glargine 4002 Study Investigators
Jun 16, 2004·Cleveland Clinic Journal of Medicine·Pasquale J Palumbo
Jan 14, 2005·The New England Journal of Medicine·Irl B Hirsch
Jan 29, 2005·Diabetes Care·Philip RaskinUNKNOWN INITIATE Study Group
Mar 5, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kent Stoneking
Apr 29, 2005·The New England Journal of Medicine·Angelika MohnFrancesco Chiarelli
May 10, 2005·The Journal of the American Board of Family Practice·M Angelyn Bethel, Mark N Feinglos
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Jan 5, 2006·Diabetes & Metabolism·B Guerci, J P Sauvanet
Jan 28, 2006·The Diabetes Educator·Jerry Meece
Mar 8, 2006·Clinical Therapeutics·Lawrence A LeiterUNKNOWN International Prandial Glucose Regulation Study Group
May 5, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E StandlUNKNOWN HOE901/4009 Study Group
Nov 23, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·R J LigthelmA Liebl
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association
Mar 17, 2007·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ildiko LingvayPhilip Raskin
Jun 30, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul S JellingerUNKNOWN ACE/AACE Diabetes Road Map Task Force
Jul 19, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Helena W RodbardUNKNOWN AACE Diabetes Mellitus Clinical Practice Guidelines Task Force
Aug 19, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·T SiegmundP-M Schumm-Draeger

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Citations

May 8, 2010·Advances in Therapy·Edith M HeintjesRon M C Herings
May 12, 2010·International Journal of Clinical Practice·P AschnerUNKNOWN Global Partnership for Effective Diabetes Management
Jul 1, 2010·Experimental Diabetes Research·Vasiliki Valla
Mar 29, 2011·Hospital Practice·Kaelen C Dunican, Alicia R Desilets
Sep 10, 2014·Medicina clínica·Jordi Mesa

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