PMID: 1437Dec 1, 1975

Demonstration of a nonadrenergic inhibitory nervous system in the trachea of the guinea pig

The Journal of Allergy and Clinical Immunology
J B Richardson, T Bouchard

Abstract

A nonadrenergic inhibitory nervous system has been demonstrated in the guinea pig trachea. Electrical field stimulation of this system, in the presence of adrenergic and cholinergic blockade, resulted in relaxation of tracheal rings contracted by the mediators of immediate hypersensitivity or histamine. The relaxation was blocked by tetrodotoxin, which indicated that nerve stimulation was responsible for the relaxation. The gastrointestinal tract, which has a similar embryological origin to the respiratory tract, also has a nonadrenergic inhibitory system. In the gastrointestinal tract, this system is thought to be responsible for the relaxation phase of peristalsis, and absence of this system, in the colon and the rectum, is thought to be an explanation for the spastic bowel in Hirschsprung's disease. It is possible that an abnormality of the respiratory nonadrenergic inhibitory system may play a role in the pathogenesis of the hyperreactive airways in asthma. The airways, due to a lack of inhibition, may be either partially contracted or unable to relax, and thus appear hyperreactive to stimuli.

References

Mar 1, 1971·The Tohoku Journal of Experimental Medicine·A Rikimaru, T Suzuki
Jan 1, 1973·The Journal of Clinical Investigation·A Tuch, S Cohen
Aug 1, 1970·British Journal of Pharmacology·J E Mills, J G Widdicombe
Dec 1, 1967·European Journal of Pharmacology·M W McCullochM J Rand

Citations

Oct 1, 1987·Agents and Actions·M E ZacourJ G Martin
Jun 1, 1982·Respiration Physiology·J F Souhrada, S Kivity
Mar 1, 1988·Respiration Physiology·L E OlsonW W Muir
Jan 1, 1992·Respiration Physiology·S DeLisleJ G Martin
Jan 1, 1979·Pharmacology & Therapeutics·H L Hahn, J A Nadel
Jan 1, 1987·Pharmacology & Therapeutics·R G Andersson, N Grundström
Jan 1, 1989·Pharmacology & Therapeutics·J A Karlsson, C G Persson
Feb 1, 1993·Pharmacology & Therapeutics·Y D Pendry
Jul 23, 1997·European Journal of Pharmacology·P NieriM C Breschi
Oct 1, 2003·Respiratory Physiology & Neurobiology·Pasquale Chitano, T M Murphy
Jan 1, 1986·Journal of Toxicology and Environmental Health·J S FedanK C Weber
May 4, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Thomas J HoffmannCharles W Emala
Feb 1, 1980·The Journal of Clinical Investigation·S E ChesrownJ M Drazen
Apr 1, 1984·Environmental Health Perspectives·R P DiAugustine, K S Sonstegard
Apr 1, 1978·British Journal of Diseases of the Chest·B J Freedman
Sep 1, 1979·The Journal of Allergy and Clinical Immunology·R C BoucherJ C Hogg
Nov 1, 1982·Experimental Lung Research·L Diamond, J B Richardson
Mar 1, 1984·Anatomia, histologia, embryologia·G R BrattonM E Tatum
Dec 8, 2005·Canadian Journal of Physiology and Pharmacology·Pasquale ChitanoThomas M Murphy
Jan 23, 2019·Integrative and Comparative Biology·Robert L Cieri
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Sep 1, 1984·British Journal of Pharmacology·L CaparrottaR M Gaion
Apr 19, 2002·Journal of Applied Physiology·Pasquale ChitanoThomas M Murphy
Aug 1, 1981·Acta Pharmacologica Et Toxicologica·N GrundströmJ E Wikberg
Jan 1, 1981·Lung·J B Richardson

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Cavia porcellus
Immediate Hypersensitivity
Inotropism
Smooth Muscle
Ovalbumin
Cholinergic Receptors
Trachea

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.