Demonstration of a primary (? genetic) defect in insulin receptors in fibroblasts from a patient with the syndrome of insulin resistance and acanthosis nigricans type A

The Journal of Clinical Endocrinology and Metabolism
C R Kahn, J Podskalny

Abstract

We have studied insulin binding to cultured skin fibroblasts from a patient with the Type A syndrome of insulin resistance and acanthosis nigricans. Insulin binding was decreased aobut 50% at low insulin concentrations. This was due to a decrease in receptor affinity and in increase in the rate of dissociation of insulin from the receptor. In addition, there was a loss of negative cooperativity, as measured by the ability of unlabeled insulin to accelerate dissociation. This defect in the receptor was stable for up to 16 passages of the cells. By contrast, binding of epidermal growth factor did not differ from control. These data suggest that the Type A syndrome of insulin resistance is due to a primary, and possibly genetic, defect in the insulin receptor.

Citations

Nov 1, 1989·Indian Journal of Pediatrics·Z Laron
Jun 1, 1981·Molecular and Cellular Endocrinology·E Van Obberghen, C R Kahn
Jul 1, 1990·The Journal of Clinical Investigation·T KadowakiS I Taylor
Jan 1, 1985·Diabetes/metabolism Reviews·S I Taylor
Apr 1, 1997·Pediatric Clinics of North America·N S Glaser
May 10, 2005·Human Reproduction Update·M A ChecaUNKNOWN Reproductive Endocrinology Interest Group of the Spanish Society of Fertility
Dec 7, 2017·Journal of Nutritional Science·Andressa R AmaralCarlos E Ambrósio
Nov 1, 1984·International Journal of Dermatology·R G Sibbald, R K Schachter
Oct 1, 1988·Acta Paediatrica Japonica; Overseas Edition·T TakumiT Matsuo
Nov 20, 2020·Journal of the Endocrine Society·Stephen I StoneDavid M Ornitz
Oct 1, 1985·The Journal of Investigative Dermatology·P Verrando, J P Ortonne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.