PMID: 6969776Dec 1, 1980Paper

Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages

The Journal of Experimental Medicine
M G ScherE R Unanue

Abstract

Previous studies have shown that Listeria monocytogenes-immune T cells, adoptively transferred into normal mice with killed Listeria organisms, induced peritoneal exudates rich in Ia-positive macrophages. We show now that culture fluids generated by Listeria-immune exudate cells and Listeria contain an activity that elicits Ia-rich exudates when injected intraperitoneally. The factor that recruits Ia-positive macrophages must be injected several times during a 2-d period for optimal demonstration of its activity. The induction of the factor is immunologically specific and requires Ia-positive macrophages, primed T lymphocytes, and antigen challenge. The factor is a nondialyzable protein and is not genetically restricted in its activity. The macrophages in the exudates induced by the factor bear Fc receptors, take up latex, synthesize I-A, but bear few C3 receptors. We have thus identified an immune mediator capable of controlling the Ia phenotype of the exudate macrophages.

References

Jan 1, 1978·Immunological Reviews·J E Niederhuber
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A G FarrE R Unanue
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C Y LuE R Unanue

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Citations

Jul 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·T SchmidR Margreiter
Jan 1, 1985·Archives of Dermatological Research·Y SonodaS Sagami
Jan 1, 1989·Archives of Gynecology and Obstetrics·D ZaccheoC Martinoli
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Mar 1, 1988·Immunology Letters·R M Steinman
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Feb 1, 1985·Journal of Neuroimmunology·G H WongJ W Schrader
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Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E J BlumenthalD W Talmage
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Nov 1, 1993·Immunobiology·M E MielkeH Hahn
Nov 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K P BeckermanP Needleman

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