PMID: 179579Apr 23, 1976

Demonstration of adenylate cyclase activity in human red blood cell ghosts

Biochimica Et Biophysica Acta
S B RodanR I Sha'afi

Abstract

The presence of adenylate cyclase (ATP pyrophosphate-lyase (cyclizing) EC 4.6.1.1) activity was demonstrated in human erythrocyte ghosts and was found to be around 3 pmol adenosine 3',5'-monophosphate (cyclic AMP) - 2 h-1 - mg-1 protein. This enzymatic activity is strongly stimulated by NaF and 5'-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium. The hormone stimulation is not potentiated by 5'-guanylylimidodiphosphate.

References

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Related Concepts

Calcium [EPC]
Adenosine
Calcium
Cyclic AMP
Norepinephrine, (+, -)-Isomer
Cyclic Adenosine Monophosphate Measurement
Fluorides
Epinephrine Measurement
Medihaler-Epi
Norepinephrine

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