PMID: 8971005Dec 1, 1996Paper

Demonstration of binding of dengue virus envelope protein to target cells

Journal of Virology
Y ChenR M Marks

Abstract

The nature of the initial interaction of dengue virus with target cells and the extent to which this interaction defines tropism are unknown. Infection of some cells may involve antidengue antibody-mediated immune adherence to cells bearing immunoglobulin Fc receptors; however, this mechanism does not explain primary infection or the infection of cells without Fc receptors. We hypothesized that dengue virus envelope protein mediates initial binding to target cells. To test this hypothesis, a recombinant chimeric form of dengue type 2 virus envelope protein was used as a probe to investigate binding to the surfaces of potential target cells. Envelope protein was expressed amino terminal to the heavy-chain constant region of human immunoglobulin G containing the Fc receptor binding motif; the binding mediated by envelope determinants was distinguishable from the binding mediated by immunoglobulin Fc determinants. We found that the recombinant chimera bound to Vero, CHO, endothelial, and glial cells through envelope protein determinants and to monocytes and U937 cells by Fc-Fc receptor interactions. The highest level of binding was to Vero cells; binding was dose and time dependent and saturable. Examination of partial-length reco...Continue Reading

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Citations

Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L J HoJ H Lai
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peggy HanJonathan Kaye
Jun 16, 2005·Journal of Virology·Jorge L Muñoz-JordánAdolfo García-Sastre
Apr 25, 2012·PLoS Neglected Tropical Diseases·Luana de BorbaClaudia N Duarte Dos Santos
Jul 11, 2012·Archives of Virology·Betânia Paiva DrumondMaurício Lacerda Nogueira
Jul 25, 2013·Human Vaccines & Immunotherapeutics·Jazmín García-MachorroLeticia Cedillo-Barrón
Aug 2, 2008·Protein Engineering, Design & Selection : PEDS·Juraina Abd-JamilSazaly AbuBakar
Jan 27, 2011·Microbiology and Immunology·Sineewanlaya WichitWipawee Jampangern
Feb 18, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·S L SeneviratneH J de Silva
Feb 17, 2009·The Journal of General Virology·Osmali OsmanShamala Devi Sekaran
Feb 5, 2011·Intervirology·Marlén Martínez-GutierrezJuan C Gallego-Gómez
Dec 11, 2013·BioMed Research International·Maria de Lourdes MuñozWilliam C Black
Dec 11, 2014·Viral Immunology·Lakshmy RamakrishnanRadhakrishnan R Nair
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May 30, 2020·Chinese Medicine·Lian Yih PongSyed Hassan Sharifah
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Feb 17, 2015·World Journal of Clinical Cases·Jayanta Samanta, Vishal Sharma
Nov 6, 2014·Molecular Medicine Reports·Zhi-Shan ZhangYan-Sheng Yan

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