Demonstration of both beta 1- and beta 2-adrenoceptors mediating relaxation of isolated ring preparations of rat pulmonary artery

British Journal of Pharmacology
S R O'Donnell, J C Wanstall

Abstract

1 Cumulative concentration-response (relaxation) curves to three beta-adrenoceptor agonists, fenoterol (beta 2-selective), isoprenaline (non-selective) and noradrenaline (beta 1-selective) were obtained on isolated ring preparations of rat pulmonary artery contracted with 15 mM KCl. alpha-Adrenoceptors and neuronal and extraneuronal uptakes were blocked with phenoxybenzamine. The agonist concentration-response curves were reproducible. 2 Responses to each of the three agonists could be blocked by the beta-adrenoceptor antagonists atenolol (beta 1-selective) or ICI 118,551 (beta 2-selective) confirming the presence of beta-adrenoceptors. 3 The relative potencies of the agonists were isoprenaline : fenoterol : noradrenaline = 100 : 38 : 1.4. This indicated that the predominant beta-adrenoceptor type was beta 2. 4 Schild plots were obtained for atenolol and ICI 118,551 using the three different agonists. For each antagonist the location of the Schild plot varied depending on which agonist was used. This indicated that the beta-adrenoceptor population mediating relaxation responses to beta-adrenoceptor agonists was not homogeneous. 5 Atenolol was most potent when noradrenaline was the agonist and ICI 118,551 was most potent when fe...Continue Reading

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Related Concepts

Adrenergic beta-Agonists
Metazoa
Novodrin
Inotropism
Muscle Relaxation Phase
Norepinephrine, (+, -)-Isomer
Pulmonary Artery Structure
August Rats
Norepinephrine Receptors
Beta-adrenergic receptor

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