Demonstration of both beta 1- and beta 2-adrenoceptors mediating relaxation of isolated ring preparations of rat pulmonary artery

British Journal of Pharmacology
S R O'Donnell, J C Wanstall


1 Cumulative concentration-response (relaxation) curves to three beta-adrenoceptor agonists, fenoterol (beta 2-selective), isoprenaline (non-selective) and noradrenaline (beta 1-selective) were obtained on isolated ring preparations of rat pulmonary artery contracted with 15 mM KCl. alpha-Adrenoceptors and neuronal and extraneuronal uptakes were blocked with phenoxybenzamine. The agonist concentration-response curves were reproducible. 2 Responses to each of the three agonists could be blocked by the beta-adrenoceptor antagonists atenolol (beta 1-selective) or ICI 118,551 (beta 2-selective) confirming the presence of beta-adrenoceptors. 3 The relative potencies of the agonists were isoprenaline : fenoterol : noradrenaline = 100 : 38 : 1.4. This indicated that the predominant beta-adrenoceptor type was beta 2. 4 Schild plots were obtained for atenolol and ICI 118,551 using the three different agonists. For each antagonist the location of the Schild plot varied depending on which agonist was used. This indicated that the beta-adrenoceptor population mediating relaxation responses to beta-adrenoceptor agonists was not homogeneous. 5 Atenolol was most potent when noradrenaline was the agonist and ICI 118,551 was most potent when fe...Continue Reading


Apr 1, 1977·British Journal of Pharmacology·N TairaS Yamashita
Oct 1, 1972·The American Journal of Physiology·G D BaronD F Bohr
Nov 1, 1967·Life Sciences·A M LandsH J Buzzo
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD


Sep 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·E N JubergP W Abel
Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Detlef BiegerR Tabrizchi
Oct 30, 1984·European Journal of Pharmacology·R A LefebvreM G Bogaert
May 31, 1990·European Journal of Pharmacology·A AbdelrahmanC C Pang
Dec 9, 2003·European Journal of Pharmacology·Mayumi MatsushitaKatsuo Koike
Jan 11, 2003·British Journal of Pharmacology·Min Wang, Mary A Lung
May 6, 2008·European Journal of Pharmacology·Khaled Al ZubairJames R Docherty
Jul 26, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·H HondaM Kondo
Jul 1, 2008·Pharmacology & Therapeutics·Daphne MerkusDirk J Duncker
Sep 1, 1988·Journal of Autonomic Pharmacology·K Vidal-Beretervide, L Castañeda
Feb 6, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Asami MoriTsutomu Nakahara
Dec 1, 1983·The Journal of Pharmacy and Pharmacology·L H Johansson, H Persson
Apr 1, 1984·British Journal of Pharmacology·S R O'Donnell, J C Wanstall
Oct 1, 1987·The Journal of Pharmacy and Pharmacology·S R O'Donnell, J C Wanstall
Jul 31, 2019·Acta Anaesthesiologica Scandinavica·Keti DallaSven-Erik Ricksten

Related Concepts

Adrenergic beta-Agonists
Muscle Relaxation Phase
Norepinephrine, (+, -)-Isomer
Pulmonary Artery Structure
August Rats
Norepinephrine Receptors
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.