Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method

Journal of Affective Disorders
Tomasz GosBernhard Bogerts

Abstract

Suicide and depression are closely related yet distinct phenomena. In both these phenomena, research has focused on central serotonergic system disturbances. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of limbic structures crucial for the regulation of emotionally influenced behaviour. The study was carried out on paraffin-embedded brains from 23 depressed patients (12 suicides and 11 non-suicides) and 26 matched controls without mental disorders. The karyometric parameters of DRN neurons were evaluated by the AgNOR silver staining method. The significant effect of suicide on the nuclear area was found in the cumulative analysis of all DRN subnuclei (ANOVA, P=0.032). A decreased mean value of this parameter was observed in the suicides group versus controls (t-test, P=0.032). This effect was especially pronounced in the violent suicide victims (t-test, P=0.001), who also demonstrated a decreased AgNOR area versus controls (t-test, P=0.007). No significant effect of depression or polarity on AgNOR parameters was found. A major limitation of this study is relatively small case number. A further limitation is given by the lack of data on drug exposure across the whole life span. Our findings sugge...Continue Reading

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Citations

Apr 25, 2012·European Archives of Psychiatry and Clinical Neuroscience·Tomasz GosBernhard Bogerts
Feb 5, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Akiko OyabuYasura Tashiro
Jun 10, 2008·Journal of Affective Disorders·Tomasz GosBernhard Bogerts
Dec 15, 2015·Cell Reports·Anne TeissierMark S Ansorge
Nov 23, 2015·European Archives of Psychiatry and Clinical Neuroscience·Marta KrzyżanowskaTomasz Gos
Mar 20, 2010·The International Journal of Neuropsychopharmacology·Beata KarolewiczGrazyna Rajkowska
Aug 6, 2014·European Archives of Psychiatry and Clinical Neuroscience·Marta KrzyżanowskaTomasz Gos
Sep 1, 2018·Sudebno-meditsinskaia ekspertiza·Ye E MorozovZh V Dorosheva
Mar 13, 2019·European Archives of Psychiatry and Clinical Neuroscience·Marta KrzyżanowskaTomasz Gos
Feb 24, 2017·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischTomasz Gos
Feb 7, 2018·Sudebno-meditsinskaia ekspertiza·Yu E Morozov, P S Velenko
Oct 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischRainer Wolf

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