PMID: 9169576Jun 1, 1997Paper

Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography

European Journal of Nuclear Medicine
K IshiiE Mori

Abstract

Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps (SPMs) and as an absolute value using conventional region of interest (ROI) settings. Twenty-eight subjects, including 14 patients with mild AD (mean age: 66.4+/-12.1 years) and 14 normal controls (65.9+/-7.3 years) were studied. Regional cerebral blood flow (CBF) was measured with H215O and positron emission tomography (PET). In the SPM analysis, the left posterior cingulate and left parietotemporal CBFs were significantly decreased in the patients with mild AD (P<0.001). At a lower statistical threshold (P<0.05), the right posterior cingulate and right parietotemporal CBFs were also significantly decreased in the AD patients. In the ROI studies, the left parietal and posterior cingulate CBFs in the patients with mild AD were significantly lower than those of the normal controls by analysis of variance and post-hoc Scheffé's test (P<0.001). We conclude that posterior cingulate perfusion is decreased in mild AD, reflecting the pathological changes and m...Continue Reading

Citations

Apr 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Kazunari IshiiEtsuro Mori
Nov 12, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Kazunari Ishii, Satoshi Minoshima
Jul 20, 2002·Journal of the Neurological Sciences·Setsu SakamotoEtsuro Mori
Jan 6, 2000·Journal of the Neurological Sciences·S Sakamoto, K Ishii
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Guido RodriguezFlavio Nobili
Sep 2, 2006·Neurological Research·Tânia Corrêa de Toledo Ferraz Alves, Geraldo F Busatto
Jun 1, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·K L BoundyC C Rowe
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars MichelsAnton F Gietl
May 15, 2019·Journal of Clinical Medicine·Karan GovindpaniAndrea Kwakowsky
Apr 15, 2014·Annals of Clinical and Translational Neurology·Duygu TosunUNKNOWN the Alzheimer’s Disease Neuroimaging Initiative
Apr 4, 2002·Experimental Aging Research·Donald R RoyallAndré Delacourte
Nov 2, 2017·Physiological Measurement·Evan P PashaHirofumi Tanaka
Jan 11, 2013·Biological & Pharmaceutical Bulletin·Megumi TsukamotoTatsuya Takagi
Nov 16, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Wei ChenKenneth Rockwood
Dec 22, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Antoine LeuzyAgneta Nordberg

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