PMID: 2512192Nov 1, 1989Paper

Demonstration of donor specific unresponsiveness in rat islet allografts: importance of transplant site for induction by cyclosporin A and maintenance

Diabetologia
T Kamei, Y Yasunami

Abstract

The purpose of the present study was to evaluate the effects of transplant site (the liver via the portal vein vs the renal subcapsular space) on islet allograft survival using cyclosporin A and also to determine whether or not the unresponsiveness obtained is donor specific and how the site selected is related to the maintenance of unresponsiveness. Prolongation of islet allograft survival (WKA/Qdj:RT1u----Lewis:RT1l) was obtained by using hand-picked clean fresh islets as donors and by s.c. administration of cyclosporin A (30 mg/kg, day 0, 1, 2) when the islets were transplanted into the liver. Eleven out of 15 recipients were normoglycaemic for more than 90 days after transplantation (control mean survival time: 4.4 +/- 1.1 days, n = 5). However, all the renal subcapsular grafts were rejected within 18 days after transplantation. Two normoglycaemic recipients bearing intrahepatic grafts were challenged with full-thickness donor-strain (WKA/Qdj) skin grafts at 120 days after the islet transplantation. Both recipients became diabetic and the skin grafts rejected within 16 days. The nine normoglycaemic recipients were made diabetic again with streptozotocin (40 mg/kg) between 90 and 120 days after the initial islet transplantat...Continue Reading

Citations

Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·X WangD C Dafoe
Apr 1, 1993·Diabetes Research and Clinical Practice·M UekiS Ikeda
Aug 18, 2000·The Journal of Surgical Research·T MakiS Ikeda
Feb 2, 2010·Journal of Korean Medical Science·Hyoung-Il KimSang-Joon Kim

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