PMID: 6161908Jan 1, 1980Paper

Demonstration of enkephalin-, substance P- and glutamate decarboxylase-like immunoreactivity in cultured cells derived from newborn rat neostriatum

Histochemistry
P PanulaJ Y Wu

Abstract

The presence of cells exhibiting leucine-enkephalin-, substance P- and glutamate decarboxylase-like immunoreactivity was demonstrated in dissociated cultures from newborn rat neostriatum. The size and shape of the enkephalin-immunoreactive cells varied, but they were generally larger than substance P- and glutamate decarboxylase-immunoreactive cells, which formed relatively uniform cell populations. Cells of apparently non-neuronal origin did not show any immunoreactivity. It is unlikely that enkephalin is present in the same cells that contain substance P or glutamate decarboxylase because of morphological differences between these cells. The possible coexistence of substance P and glutamate decarboxylase in the same cells however, could not be excluded. The results of this study confirm that the cell bodies of neurons containing three possible neurotransmitters are located in the neostriatum.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C BrandonJ Y Wu
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SimantovS H Snyder
Aug 25, 1977·Nature·H PollardJ C Schwartz
Apr 1, 1978·Journal of Neurochemistry·J Y WuE Wong
Jan 1, 1979·Neuroscience·P PanulaH Hervonen
Nov 11, 1977·Brain Research·K GaleA Ghidotti
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K SaitoJ E Vaughn
Jan 1, 1973·Journal of Neurobiology·J T CoyleJ Axelrod
Jan 1, 1969·Brain Research·S Varon, C W Raiborn
Jul 1, 1973·Journal of Neurochemistry·T MatsudaE Roberts
Jan 11, 1974·Brain Research·K SaitoE Roberts

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