PMID: 7085428Apr 1, 1982Paper

Demonstration of failure of body plethysmography in airway obstruction

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D O RodensteinC Francis


To demonstrate the role of extrathoracic airways in the overestimation of lung volumes by body plethysmography in airway obstruction, we induced in six normal subjects an artificial airway stenosis by inflating a balloon in the lower trachea. We measured thoracic gas volume in a body plethysmograph simultaneously from mouth pressure (Pm) vs. plethysmographic volume (Vbox) (TGVm) and from esophageal pressure (Pes) vs. Vbox (TGVes). During control measurements there was no difference between TGVm and TGVes (P greater than 0.1) in any subject. Balloon inflation (B) resulted in a significant (P less than 0.01) decrease of specific airway conductance (sGaw) from a mean value of 0.199 +/- 0.66 (SD) to 0.025 +/- 0.01 cmH2O-1 . s-1. TGVm significantly (P less than 0.02) exceeded TGVes in every subject (mean diff 1.24 +/- 0.56 liters) and Pm lagged behind Pes. In two subjects studied at different levels of airway obstruction we found a significant (P less than 0.05) correlation between TGVm-TGVes difference and sGaw. Bypassing the extrathoracic airways by a cuffed endotracheal tube resulted in each case in a degree of airway obstruction comparable to that during balloon inflation (sGaw 0.019 +/- 0.004 cmH2O-1 . s-1), but no difference b...Continue Reading


Sep 30, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·M Oswald-MammosserEvelyne Lonsdorfer-Wolf
Jan 1, 1991·Pediatric Pulmonology·A L Coates, J Stocks
Mar 5, 1992·The New England Journal of Medicine·H L Manning
May 1, 1992·Medical & Biological Engineering & Computing·P Gizdulich
Jul 16, 2005·Experimental Lung Research·Andrew HoffmanEdward Ingenito
Sep 3, 1999·Journal of the Royal Society of Medicine·C K van der Ent, P L Brand
Apr 29, 2006·Journal of Applied Physiology·Tibor Z JánosiZoltán Hantos
Aug 26, 2006·Journal of Applied Physiology·D C Stănescu
Oct 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T J Gal

Related Concepts

Airway Resistance
False Positive Reactions
Intubation, Intratracheal
Plethysmography, Whole Body

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Related Papers

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D O Rodenstein, D C Stănescu
Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
D C StănescuK P Van de Woestijne
© 2021 Meta ULC. All rights reserved