PMID: 101214Aug 15, 1978

Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats

The Biochemical Journal
G J Wishart

Abstract

After the administration of 3-methylcholanthrene to adult male rats, activities of hepatic UDP-glucuronosyltransferase towards six from a group of 12 substrates were stimulated by 250-350%. Activities towards the remaining six substrates were unaffected. Conversely, after phenobarbital administration, activities formerly stimulated by 3-methylcholanthrene remained unchanged, and the other six activities were stimulated by 160-280%. The relationship of these two groups of transferase activities to other evidence suggesting the same heterogeneity of the enzyme is discussed.

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·K W BockJ Bircher
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·K W BockW Lilienblum
May 1, 1983·Acta Pharmacologica Et Toxicologica·J A HolmeE Dybing
Jul 1, 1980·British Journal of Clinical Pharmacology·J C MucklowC T Dollery
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·K W Bock
Mar 1, 1990·Human & Experimental Toxicology·A VianiG M Pacifici
Sep 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M PacificiA R Boobis
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R ChowdhuryI M Arias
Oct 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H P Illing, E S House
Nov 2, 1987·European Journal of Biochemistry·T Kimura, I S Owens
Jan 8, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M IshizukaS Fujita
Dec 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J A BoutinG Siest
Mar 1, 1980·Archives of Toxicology·F J Wiebel, J Singh
Apr 5, 1983·European Journal of Biochemistry·H Pfeil, K W Bock
Jul 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B AntoineG Siest
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P L JansenK W Bock
Jan 1, 1987·Archives of Toxicology·K W BockB S Bock-Henning
Oct 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H C LiT Gessner
Jan 1, 1996·Drug Metabolism and Drug Interactions·P K YeungJ Jordan

Related Concepts

Enzyme Activation
Liver
Methylcholanthrene
Luminal
Substrate Specificity
UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase

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