Demonstration of hematopoietic stem cells in ginbuna carp (Carassius auratus langsdorfii) kidney

Developmental and Comparative Immunology
Isao KobayashiTeruyuki Nakanishi

Abstract

A model system of ginbuna carp (clonal triploid fish, Carassius auratus langsdorfii) and ginbuna-goldfish hybrids (tetraploid fish, having three sets of chromosomes from a triploid clone and a haploid set of chromosomes from goldfish) was employed to demonstrate the presence of hematopoietic stem cells (HSCs) in kidney hematopoietic tissues. Kidney hematopoietic cells were obtained from ginbuna carp (S3n, donor) and injected into a ginbuna-gold fish hybrid (S4n, recipient) via the caudal sinus. The percentage of S3n cells in the S4n blood was measured by flow cytometry by the difference of DNA content from 3 to 18 months after the injection. Donor-derived major types of blood cells including erythrocytes, thrombocytes, neutrophils, basophils, monocytes, T and B lymphocytes were detected in the recipient blood over a long period (9-18 month posttransplantation). Moreover, recipient lympho-hematopoietic organs such as head kidney, body kidney, spleen, and thymus were reconstituted by donor cells. These results indicate that long-term multipotent repopulating HSCs reside in the donor kidney.

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Citations

Oct 21, 2010·Fish Physiology and Biochemistry·Elżbieta Kondera
Oct 23, 2012·Fish Physiology and Biochemistry·Elzbieta Kondera, Malgorzata Witeska
Jan 24, 2016·Developmental and Comparative Immunology·Isao KobayashiTadaaki Moritomo
Nov 3, 2012·Developmental and Comparative Immunology·Rute D PintoNuno M S dos Santos
Nov 3, 2010·Ecotoxicology and Environmental Safety·Boris JovanovićDušan Palić
May 13, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mirella VazzanaNicolò Parrinello
Apr 21, 2009·Veterinary Immunology and Immunopathology·Fumihiko KatakuraTeruyuki Nakanishi
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
Aug 5, 2008·Veterinary Immunology and Immunopathology·Isao KobayashiTeruyuki Nakanishi
Nov 30, 2006·Developmental and Comparative Immunology·Isao KobayashiTeruyuki Nakanishi
Nov 12, 2015·BioMed Research International·Shun Maekawa, Takashi Kato
Jul 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Aleksandra Y AndreyevaTatiana A Kukhareva
Oct 4, 2019·Scientific Reports·Isao KobayashiDavid Traver
Sep 11, 2007·The Journal of Biological Chemistry·Patrick C HaningtonMiodrag Belosevic
May 25, 2010·Developmental and Comparative Immunology·Yasuhiro ShibasakiTeruyuki Nakanishi
Jan 29, 2011·Developmental and Comparative Immunology·Hideaki TodaTeruyuki Nakanishi

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