Demonstration of increased collagen synthesis in irradiated human skin in vivo

British Journal of Cancer
P AutioT Lahtinen

Abstract

Fibrosis is a common side-effect of radiation therapy. As a complex network of cytokines and other mediators plays a central role in the process leading to fibrosis, we used an in vivo method to measure skin collagen synthesis, taking into account the physiological conditions. We determined suction blister (i.e. interstitial) fluid concentrations of types I and III procollagen propeptides, reflecting types I and III collagen synthesis, in irradiated and unirradiated skin of breast cancer patients 1-5 years after surgery and radiation therapy, hence using the patients as their own controls. The mean concentrations of the measured collagen markers were approximately two times higher in the irradiated skin than in the unirradiated contralateral breast skin. The difference slowly diminishes with time. These results indicate that abundant collagen synthesis in the irradiated skin continues several years after discontinuation of the radiation therapy, leading to fibrosis. The method outlined here offers a new in vivo perspective to study events leading to radiation fibrosis.

Citations

Jun 2, 2009·Aesthetic Plastic Surgery·Pietro PanettiereDanilo Accorsi
Apr 25, 2014·Advances in Wound Care·Sadanori Akita
Jun 6, 2020·European Radiology Experimental·Matheus da Silva SantinJosé Rosa Gomes
Apr 25, 2014·Cell Biochemistry and Biophysics·Semra Tepe ÇamÖmür Çelikbıçak
Jan 17, 2020·Plastic and Reconstructive Surgery. Global Open·Kristina M CrawfordMatthew R Endara
Jun 17, 2020·Plastic and Reconstructive Surgery. Global Open·Lipi ShuklaRamin Shayan
Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M SassiJ Risteli
Oct 5, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John Yarnold, Marie-Catherine Vozenin Brotons

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