PMID: 6980812Sep 1, 1982Paper

Demonstration of non-specific B-cell stimulation in patients with cirrhosis

Gut
G HoldstockE L Krawitt

Abstract

Using a sensitive enzyme-linked immunosorbent assay technique to measure immunoglobulins produced by peripheral lymphocytes, patients with cirrhosis with, and without, hypergammaglobulinaemia were found to produce significantly more spontaneous IgG than controls (p less than 0.005). There was no difference in IgG production when pokeweed mitogen, a T-cell dependent B-cell mitogen, was added to the system. Contrary to our findings in a T-cell proliferative assay, there was no evidence of increased prostaglandin-producing suppressor cell activity in this system. To study the importance of B-cell stimulation in cirrhotic hyperglobulinaemia, normal mononuclear cells were exposed either to cirrhotic or to control sera before measuring spontaneous IgG production. Cells exposed to cirrhotic sera produced significantly more IgG than those exposed to the control sera (p less than 0.02). These findings suggest that non-specific B-cell activity occurs with patients in cirrhosis and it is argued that the severity of the hypergammaglobulinaemia in patients with cirrhosis is more likely to depend on the degree of non-specific B-cell stimulation than on the competence of the immunoregulatory system.

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Citations

Jul 1, 1987·Baillière's Clinical Gastroenterology·J Neuberger, R Williams
Aug 1, 1993·Alcoholism, Clinical and Experimental Research·C J GrossmanP S Gartside
May 19, 2001·Mayo Clinic Proceedings·A DispenzieriR A Kyle
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroyoshi DoiDavid E Kaplan
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·R D Johnson, R Williams
Jun 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lisbet GrønbækPeter Jepsen
Sep 14, 2010·Medical Hypotheses·Georgios Kalambokis, Epameinondas V Tsianos
Dec 2, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Irene CacciolaGiovanni Raimondo
Jan 1, 1983·Acta Medica Scandinavica·C Gluud, U Tage-Jensen

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