PMID: 107869Feb 1, 1979

Demonstration of protein AA in subcutaneous fat tissue obtained by fine needle biopsy

Annals of the Rheumatic Diseases
P WestermarkE Olding-Stenkvist


Polarisation microscopy of material obtained by fine needle biopsy of subcutaneous tissue and stained with Congo red is a simple and reliable method for the diagnosis of systemic amyloidosis. It cannot, however, be used to differentiate histologically between different forms of amyloidosis. In the present study extracts of material obtained by fine needle biopsy of subcutaneous fat tissue from 13 patients were examined by double immunodiffusion with an antiserum against protein AA, a unique protein which forms a major part of the fibrils in secondary amyloidosis. Five of the patients showed amyloid deposits round the fat cells by conventional microscopy. In 3 of these, all with rheumatoid arthritis, protein AA was detected. Eight patients without amyloidosis and 2 with myelomatosis and amyloidosis showed no reaction with antiprotein AA antiserum. Thus the material obtained by fine needle biopsy of subcutaneous tissue could be used not only for the histological diagnosis of amyloidosis but also for a classification of systemic amyloidosis into secondary or primary based on the type of amyloid fibril protein involved.


May 27, 1999·Annals of the Rheumatic Diseases·Bouke P C HazenbergMartin H van Rijswijk
Dec 1, 1982·Pathology, Research and Practice·Y LevoA Laufer
Mar 24, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Mohamed YounesNaceur Bergaoui
Mar 1, 1987·The American Journal of Medicine·M A DustonA S Cohen
Nov 15, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·P Westermark
Mar 29, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Lawrence G KettwichArthur D Bankhurst
Mar 1, 1981·International Journal of Dermatology·R A Kyle
Jan 1, 1995·Scandinavian Journal of Rheumatology·P Westermark
Oct 1, 1990·Arthritis and Rheumatism·S YurdakulH Yazici

Related Concepts

Fat Pad
Amyloid Fibrils
Amyloid Protein AA
Needle Biopsy Procedure
Immunodiffusion Measurement

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