PMID: 9541237Apr 16, 1998Paper

Demonstration of putative Ca-binding domains in dentin matrix of rat incisors after daily injections of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP)

European Journal of Oral Sciences
Y TakanoN Kurosaki

Abstract

In order to clarify the initial process of dentin mineralization, the inhibitory effect of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) on dentin mineralization was investigated. Rats (100 g) were subcutaneously injected with HEBP (8 mg P/kg) for 7 or 14 d, and the incisors were processed for Ca histochemistry and/or electron microscopy. HEBP-treated incisors demonstrated ladder-like alternate rows of mineralized and non-mineralized dentin at the apical end. GBHA revealed moderate Ca reactions in the non-mineralized circumpulpal dentin matrix where electron microscopy revealed rich distribution of fine mesh-like electron-dense material. Non-mineralized mantle dentin matrix was negative for Ca but contained numerous matrix vesicles (MVs) filled with crystalline and/or amorphous mineral deposits. Mineralization of circumpulpal dentin occurred independently of MV-rich mantle dentin layer in affected specimens. Our data provide histochemical evidence of possible Ca-binding property of the circumpulpal dentin matrix and its absence in the mantle dentin where MV-mediated mineralization occurs. In the mantle dentin, HEBP does not interfere with crystal growth in MVs but inhibits its outgrowth after membrane rupture. It is proposed th...Continue Reading

Citations

Feb 20, 2016·Environmental Toxicology and Pharmacology·Ana Prates SoaresAlexandre Ribeiro do Espírito Santo
Feb 10, 2007·Bone·K VerdelisA L Boskey
Feb 8, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Luciana F MassaVictor E Arana-Chavez
Aug 23, 2008·Journal of Dental Research·N R KaipaturM D McKee
Dec 28, 2002·Archives of Histology and Cytology·Eiko Watanabe, Yoshiro Takano
Jan 1, 1998·Journal of Cellular Biochemistry·Adele L Boskey

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