Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography

European Journal of Drug Metabolism and Pharmacokinetics
I SzinaiA Magyar


The oral anticoagulant warfarin and its 14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance of levo-warfarin and its metabolites to be substantially slower than that of dextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines.


Nov 1, 1990·Journal of Pharmacological Methods·R d'ArgyS Ullberg
Sep 1, 1989·Trends in Pharmacological Sciences·M SimonyiB Testa
Mar 1, 1986·British Journal of Clinical Pharmacology·I A ChoonaraB K Park
Jun 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·A Yacobi, G Levy
Jul 1, 1984·Medicinal Research Reviews·M Simonyi


Jul 1, 1995·European Journal of Drug Metabolism and Pharmacokinetics·V JakovljevićB Banić
May 28, 1993·Biochimica Et Biophysica Acta·M D'ErmeP Caiafa
Apr 16, 1991·Biochimica Et Biophysica Acta·C Sapienza
Nov 17, 1980·Biochemical and Biophysical Research Communications·M SimonyiL Otvös

Related Concepts

Carbon Radioisotopes
August Rats
Molecular Stereochemistry
Drug or Chemical Tissue Distribution
Rats, Laboratory

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.