Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography

European Journal of Drug Metabolism and Pharmacokinetics
I SzinaiA Magyar

Abstract

The oral anticoagulant warfarin and its 14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance of levo-warfarin and its metabolites to be substantially slower than that of dextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines.

References

Nov 1, 1990·Journal of Pharmacological Methods·R d'ArgyS Ullberg
Sep 1, 1989·Trends in Pharmacological Sciences·M SimonyiB Testa
Mar 1, 1986·British Journal of Clinical Pharmacology·I A ChoonaraB K Park
Jun 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·A Yacobi, G Levy
Jul 1, 1984·Medicinal Research Reviews·M Simonyi

Citations

Jul 1, 1995·European Journal of Drug Metabolism and Pharmacokinetics·V JakovljevićB Banić
May 28, 1993·Biochimica Et Biophysica Acta·M D'ErmeP Caiafa
Apr 16, 1991·Biochimica Et Biophysica Acta·C Sapienza
Nov 17, 1980·Biochemical and Biophysical Research Communications·M SimonyiL Otvös

Related Concepts

Metazoa
Autoradiography
Carbon Radioisotopes
August Rats
Molecular Stereochemistry
Drug or Chemical Tissue Distribution
Gen-Warfarin
Rats, Laboratory

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