PMID: 6170960Jan 1, 1980Paper

Demonstration of substance P in aortic nerve afferent fibers by combined use of fluorescent retrograde neuronal labeling and immunocytochemistry

Peptides
C J HelkeD M Jacobowitz

Abstract

Combined use of the intraaxonal retrograde transport of the fluorescent marker 'true blue' with substance P (SP) immunocytochemistry has been used to trace the nodose ganglion projections of SP-containing neurons of the aortic depressor nerve. It has been found that (1) SP immunoreactive (SP-I) cell bodies are clearly demonstrable in clusters in the rostral part of the nodose ganglion without the aid of colchicine pretreatment; (2) 'true blue' is retrogradely transported to the nodose ganglion following its application to the central cut end of the aortic nerve; (3) 'true blue' fluorescence and SP fluorescent immunoreactivity can be visualized in the same tissue section and certain cell bodies in the nodose ganglia contain both SP-I and retrogradely transported 'true blue'. These results indicate that the aortic nerve which projects from the aortic arch baro- and/or chemoreceptors to brainstem vasomotor centers contains SP-I afferent fibers which emanate form the nodose ganglion.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Jun 30, 1975·Annals of the New York Academy of Sciences·T HökfeltM Goldstein
Jul 1, 1979·Acta Physiologica Scandinavica·A BillG Nilsson
Mar 1, 1980·Brain Research Bulletin·D M Jacobowitz, C J Helke
Apr 27, 1956·The Journal of Physiology·W W DOUGLASW SCHAUMANN
Nov 8, 1958·Nature·C C CURTAIN

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Citations

Jul 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J Donnerer, F Lembeck
Apr 1, 1984·Journal of the Autonomic Nervous System·F Barja, R Mathison
Feb 1, 1985·Journal of the Autonomic Nervous System·P R Howe
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Mar 6, 2004·Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·Ge XiongYasuo Sugiura
Mar 22, 2014·Physiology & Behavior·Guillaume de Lartigue
Feb 1, 1985·Journal of the Autonomic Nervous System·P J GallagherS W White
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
Mar 15, 1983·Biochemical Pharmacology·E C KulakowskiW Lovenberg
Mar 28, 2013·Clinical Science·Mariela M GironacciBruno D Cerrato
Oct 18, 2002·Microscopy Research and Technique·Hiroyuki Ichikawa
Jan 1, 1983·Annals of the New York Academy of Sciences·N I SwislockiE B Cunningham
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Debra I DizDavid B Averill
Sep 14, 1999·The American Journal of Physiology·W FanM C Andresen
Nov 8, 1987·The Journal of Comparative Neurology·K B Thor, C J Helke
Oct 2, 1995·The Journal of Comparative Neurology·X F Huang, G Paxinos

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