Demonstration of the effectiveness of zinc in diarrhoea of children living in Switzerland

European Journal of Pediatrics
Pierre Alex CrisinelMario Gehri

Abstract

We designed a double-blinded randomized clinical trial of zinc (10 or 20 mg of zinc sulphate for 2-5 month-old or 6-59 month-old children, respectively, during 10 days) vs. placebo in otherwise healthy children aged 2 months to 5 years who presented with acute diarrhoea (i.e. ≥3 stools/day for less than 72 h). Eighty-seven patients (median age 14 months; range 3.1-58.3) were analysed in an intention-to-treat approach. Forty-two patients took zinc and 45 placebo. There was no difference in the duration nor in the frequency of diarrhoea, but only 5% of the zinc group still had diarrhoea at 120 h of treatment compared to 20% in the placebo group (P = 0.05). Thirty-one patients (13 zinc and 18 placebo) were available for per-protocol analyses. The median (IQR) duration of diarrhoea in zinc-treated patients was 47.5 h (18.3-72) and differed significantly from the placebo group (median 76.3; IQR 52.8-137) (P = 0.03). The frequency of diarrhoea was also lower in the zinc group (P = 0.02). zinc treatment decreases the frequency and severity of diarrhoea in children aged 2 months to 5 years living in Switzerland. However, the intention-to-treat analysis reveals compliance issues that question the proper duration of treatment and the cho...Continue Reading

References

Mar 22, 2003·Annals of Tropical Paediatrics·Nagla'a Al-SonboliLuis E Cuevas
Dec 25, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazi Mirajul HoqueHenry J Binder
Dec 16, 2005·Archives of Disease in Childhood·P BoranM K Gokduman
Jan 26, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Nazan DalgicOzlem Hasim
Jun 30, 2011·Indian Journal of Pharmacology·Chaitali Bajait, Vijay Thawani
Jul 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Nitya WadhwaShinjini Bhatnagar
May 15, 2012·Lancet·Li LiuUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Luca Ronfani

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Citations

Mar 11, 2016·The Journal of Nutrition·Janet C KingDaniel J Raiten
Dec 2, 2017·Archives of Disease in Childhood·Will Creasy, Clemmie Stebbings
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Humphrey Wanzira
Jan 30, 2020·Current Infectious Disease Reports·Ivan D FlorezClaudia P Beltrán-Arroyave
Sep 18, 2020·International Journal of Preventive Medicine·Sanaz MehrabaniReza Tarahomi
Feb 13, 2021·Medical Sciences : Open Access Journal·Randal K BuddingtonScott C Howard

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