Demonstration of the high-affinity IgE receptor on human Langerhans cells in normal and diseased skin

The British Journal of Dermatology
J GrabbeB M Czarnetzki

Abstract

Epidermal dendritic cells of normal adult foreskin, and of lesional skin from patients with atopic eczema, stasis eczema and urticaria pigmentosa are shown to be highly reactive with two different monoclonal antibodies (29C6 and 6F7) specific for extracellular domains of the alpha-chain of the high-affinity IgE receptor. By their distribution pattern, the reactive cells are Langerhans cells. This is confirmed by immunoelectron microscopic demonstration of Birbeck granules in the labelled epidermal cells. Very weak staining is observed on the same cells with an antibody (Tü1) against the low-affinity IgE receptor. Pre-incubation of the sections with IgE partially blocks binding of 6F7 antibody. Langerhans cells, together with dermal mast cells, can therefore bind IgE with high efficiency, and may in this way participate in IgE-mediated cutaneous diseases.

References

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Citations

Jan 1, 1994·Archives of Dermatological Research·K HamannB M Czarnetzki
Jan 1, 1995·Archives of Dermatological Research·N HaasB M Czarnetzki
Jan 1, 1995·Archives of Dermatological Research·N HaasB M Czarnetzki
Feb 7, 2001·Allergy·A Wollenberg, T Bieber
Apr 1, 1996·Immunology and Cell Biology·G C MuddeE M Poellabauer
Dec 21, 2000·Clinical and Experimental Dermatology·A WollenbergT Bieber
Mar 1, 1995·Allergy·G C MuddeC A Bruijnzeel-Koomen
Jan 5, 2000·The Journal of Investigative Dermatology·B HermesB M Henz
Nov 1, 1996·Journal of the American Academy of Dermatology·S E WhitmoreJ R Nethercott
May 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P BanerjeeM H Rustin
Mar 10, 2010·Immunology and Cell Biology·Adelheid Elbe-Bürger, Christopher Schuster
May 1, 2021·International Journal of Molecular Sciences·Martin VossAnne Dudeck

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