PMID: 9188927Apr 1, 1997Paper

Demonstration of the high-affinity IgE receptor (Fc epsilon RI) on Langerhans' cells of diseased nasal mucosa

Allergy
N HaasB M Czarnetzki

Abstract

Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high-affinity IgE receptor (Fc epsilon RI). Using two highly specific antibodies against the antibody-binding alpha-chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immunoelectron microscopy that Langerhans' cells of diseased nasal mucosa can express the Fc epsilon RI. Tissue sections from hyperplastic nasal conchae and nasal polyps of atopic and nonatopic patients have shown no basic differences in epithelial Fc epsilon RI-bearing cells. Only a few cells expressed the low-affinity IgE receptor (Fc epsilon RII) (Tü1 antibody) in some sections. These findings suggest that Langerhans' cells play an important role in the induction of transepithelial IgE-mediated allergy and in the mediation of inflammation of the nasal mucosa via their Fc epsilon RI.

References

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Citations

Dec 22, 1999·Allergy·W J Fokkens
Jun 6, 1998·American Journal of Respiratory Cell and Molecular Biology·O GhaffarQ Hamid
Nov 3, 2009·Immunology and Allergy Clinics of North America·Cornelis M van DrunenWytske J Fokkens
Dec 22, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J O Warner, J Bousquet
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Nov 9, 2000·American Journal of Rhinology·W J FokkensA KleinJan

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