PMID: 7932390Mar 1, 1994Paper

Demonstration of the low affinity alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-R alpha) on human trophoblast and uterine cells

Journal of Reproductive Immunology
P P JokhiY W Loke

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a classical haematopoietic cytokine which has also been implicated in placental growth and development. In this study we have performed a detailed immunohistological localization of the low affinity GM-CSF receptor (GM-CSF-R alpha) in human first trimester implantation site and non-pregnant endometrium. We have also investigated receptor expression and GM-CSF binding in vitro by normal first trimester trophoblast using flow cytometric analysis and compared this with JEG-3 and JAR choriocarcinoma cells. In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSF-R was not expressed by glands in proliferative phase endometrium but began to appear during the secretory phase, suggesting hormonal regulation of the receptor on uterine glandular epithelium. Flow cytometric comparison of normal isolated first trimes...Continue Reading

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Citations

Apr 30, 1999·Journal of Reproductive Immunology·A A de MoraesP J Hansen
Feb 21, 2009·Biology of Reproduction·Amanda N Sferruzzi-PerriSarah A Robertson
Jan 15, 2000·Nihon rinsho. Japanese journal of clinical medicine·F Kimura
Aug 15, 2008·Human Reproduction Update·Scott M Nelson, Ian A Greer
Jan 12, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Monika SiwetzMartin Gauster
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Kristijan CupurdijaPeter Sedlmayr
Mar 20, 1999·Biology of Reproduction·D Fairchild Benyo, K P Conrad
Apr 22, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Paul T JubinskyDavid P Witte
Jan 23, 1999·Biology of Reproduction·S A RobertsonR F Seamark
Dec 31, 2014·Endocrine Reviews·George A ThouasDavid K Gardner
Dec 10, 1999·American Journal of Reproductive Immunology : AJRI·Y Zhao, N Chegini
Dec 11, 2020·American Journal of Reproductive Immunology : AJRI·Zahra Bahrami-AslFrancisco Dominguez
Jan 21, 2020·The American Journal of Pathology·Rachel G SinkeyCharles J Lockwood
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Masatoshi HayashiTakeyoshi Ohkura
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Lorena Fernandez-GonzalezKatarina Jewgenow

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